ABSTRACT:
Objective: The In vivo antioxidant and modulating enzymes of the Wattakaka volubilis leaves and kaempferol against aluminium sulphate induced toxicity in rats. Methods: Hepatotoxic rats were treated with methanol extract of Wattakaka volubilis and kaempferol for a period of 14 days. Results: The activities of LPO, SOD, CAT, GSH, GR, GPx and membrane bound enzymes, Mitochondrial enzymes in liver. The activities of all parameters registered a significant (p=0.001) alteration in aluminium sulphate treated rats, which were significantly recovered towards an almost normal level in rats co-administered with Wattakaka volubilis extract in a dose-dependent manner. All the biochemical investigations were confirmed by the observations and compared with the standard drug silymarin. Conclusion: Antioxidant enzymes, membrane bound ATPase, mitochondrial TCA cycle enzymes enzymes modulated by kaempferol on aluminium sulphate induced liver toxicity.