In vivo Antioxidant and Modulating Enzymes of Wattakaka Volubilis and Kaempferol against Aluminium Sulphate Induced in Liver Toxicity

Usharani S; R. Anuradha

doi:10.5958/0974-360X.2018.00512.7

Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)

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In vivo Antioxidant and Modulating Enzymes of Wattakaka Volubilis and Kaempferol against Aluminium Sulphate Induced in Liver Toxicity

Author(s): Usharani S, R. Anuradha

Email(s): usharani1886@gmail.com

DOI: 10.5958/0974-360X.2018.00512.7

Address: Usharani S* , R. Anuradha
PG and Research Department of Biochemistry, S.T.E.T.Women’s College, Sundarakottai, Mannargudi–614001. Tamil Nadu, India.
*Corresponding Author

Published In: Volume - 11, Issue - 7, Year - 2018

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ABSTRACT:
Objective: The In vivo antioxidant and modulating enzymes of the Wattakaka volubilis leaves and kaempferol against aluminium sulphate induced toxicity in rats. Methods: Hepatotoxic rats were treated with methanol extract of Wattakaka volubilis and kaempferol for a period of 14 days. Results: The activities of LPO, SOD, CAT, GSH, GR, GPx and membrane bound enzymes, Mitochondrial enzymes in liver. The activities of all parameters registered a significant (p=0.001) alteration in aluminium sulphate treated rats, which were significantly recovered towards an almost normal level in rats co-administered with Wattakaka volubilis extract in a dose-dependent manner. All the biochemical investigations were confirmed by the observations and compared with the standard drug silymarin. Conclusion: Antioxidant enzymes, membrane bound ATPase, mitochondrial TCA cycle enzymes enzymes modulated by kaempferol on aluminium sulphate induced liver toxicity.

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Cite this article:
Usharani S , R. Anuradha. In vivo Antioxidant and Modulating Enzymes of Wattakaka Volubilis and Kaempferol against Aluminium Sulphate Induced in Liver Toxicity. Research J. Pharm. and Tech 2018; 11(7): 2768-2775. doi: 10.5958/0974-360X.2018.00512.7

Cite(Electronic):
Usharani S , R. Anuradha. In vivo Antioxidant and Modulating Enzymes of Wattakaka Volubilis and Kaempferol against Aluminium Sulphate Induced in Liver Toxicity. Research J. Pharm. and Tech 2018; 11(7): 2768-2775. doi: 10.5958/0974-360X.2018.00512.7 Available on: https://rjptonline.org/AbstractView.aspx?PID=2018-11-7-11