Author(s): Dewi Sulthoniyah, Riesta Primaharinastiti, Febri Annuryanti

Email(s): riesta-p-h@ff.unair.ac.id

DOI: 10.5958/0974-360X.2018.00475.4   

Address: Dewi Sulthoniyah, Riesta Primaharinastiti*, Febri Annuryanti
Departement of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Airlangga Jl. Dharmawangsa Dalam 4-6, Surabaya 60286, East Java, Indonesia
*Corresponding Author

Published In:   Volume - 11,      Issue - 6,     Year - 2018


ABSTRACT:
Flame Atomic Absorption Spectrophotometry (FAAS) has been developed for determination of iron (Fe) in multivitamin mineral capsule dosage form. The method of sample preparation used combination of dry ashing (450 ± 20°C for 2 hours or until it becomes ashes) and wet ashing with a mixture H2O2 30%, HCl 6N, and HNO3 65%. The method validation comprises of the study of selectivity, linearity, accuracy, and precision. The proposed method was linear over the concentration ranges of 2-8 µg/mL. The regression was y=0,0435x+0,0237 with the correlation coefficient (r) obtained for those regression is 0,9996 and the relative process standard deviation value (Vxo) is 1,39%. The accuracy of Fe was 100,12%. The precision coefficients of variation in the range 0,99% for repeatability and 0,83% for intermediate precision. The method was successfully applied for determination of iron (Fe) in multivitamin mineral capsule dosage form. The conclusion of this study that the method of FAAS (Flame Atomic Absorption Spectrophotometry) meets the validation requirements in selectivity, linearity, accuracy, and precision.


Cite this article:
Dewi Sulthoniyah, Riesta Primaharinastiti, Febri Annuryanti. Method Validation of Flame Atomic Absorption Spectrophotometry (FAAS) for Determination of Iron (FE) in Multivitamin Mineral Capsule Dosage Form. Research J. Pharm. and Tech 2018; 11(6): 2569-2574. doi: 10.5958/0974-360X.2018.00475.4

Cite(Electronic):
Dewi Sulthoniyah, Riesta Primaharinastiti, Febri Annuryanti. Method Validation of Flame Atomic Absorption Spectrophotometry (FAAS) for Determination of Iron (FE) in Multivitamin Mineral Capsule Dosage Form. Research J. Pharm. and Tech 2018; 11(6): 2569-2574. doi: 10.5958/0974-360X.2018.00475.4   Available on: https://rjptonline.org/AbstractView.aspx?PID=2018-11-6-76


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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