ABSTRACT:
Simple, specific, accurate and precise spectrophotometric methods were developed and validated for simultaneous estimation of Benzocaine and Phenazonein their pure form and pharmaceutical dosage form. Two spectrophotometric methods were applied: derivative ratio spectra and absorbance ratio method. The linearity range for the spectrophotometric methods was found to be (0.3-30µg/mL) and (0.7-30µg/mL) for benzocaine and phenazone respectively in derivative ratio method and to be (0.5-27µg/mL) and (0.7-30µg/mL) for benzocaine and phenazone respectively in absorbance ratio method. Both methods were simple, sensitive, ecofriendly and don’t need a special program, so they could be easily applied as alternative methods to LC methods in quality control laboratories lacking the required facilities for those techniques.
Cite this article:
Warid Khayata, Duaa AL Zakri. Two Simple Spectrophotometric Methods for the Simultaneous Determination of Benzocaine and Phenazone. Research J. Pharm. and Tech 2018; 11(6): 2507-2511. doi: 10.5958/0974-360X.2018.00463.8
Cite(Electronic):
Warid Khayata, Duaa AL Zakri. Two Simple Spectrophotometric Methods for the Simultaneous Determination of Benzocaine and Phenazone. Research J. Pharm. and Tech 2018; 11(6): 2507-2511. doi: 10.5958/0974-360X.2018.00463.8 Available on: https://rjptonline.org/AbstractView.aspx?PID=2018-11-6-64