Author(s): Saad Antakli, Leon Nejem, Ahmad Kullah

Email(s): antakli@scs-net.org

DOI: 10.5958/0974-360X.2018.00436.5   

Address: Saad Antakli, Leon Nejem, Ahmad Kullah
Department of Chemistry, Faculty of Science, University of Aleppo, Syria.
*Corresponding Author

Published In:   Volume - 11,      Issue - 6,     Year - 2018


ABSTRACT:
Spectrophotometric method was developed and applied for simultaneous determination of Hydrochlorothiazide (HYD) individually or with combination with Triamterene (TRM) in some pharmaceutical formulations. This new method was applied to determine (HYD) and (TRM) in several Syrian trademark drugs such as: (Biazid 50 mg (TRM) and 25 mg (HYD)/tab, Hydrochlorothiazide Alfares 25 mg/tab, Hydrochlorothiazide Alfares 12.5 mg/tab, DIUREX 25 mg/tab). Derivative spectrophotometric (DS) method was applied for the determination of (HYD) and (TRM), respectively. (HYD) was determined by first derivative spectrophotometry at 280.5 nm (1D 280.5), and (TRM) was determined by first derivative spectrophotometry at 379 nm (1D 379). Linearity ranges were 0.64 – 28.8 ??g/mL for (HYD) and 0.8 – 19.2 ??g/mL for (TRM), regression analysis showed a good correlation coefficients R2 = 0.9997 and R2 = 0.9999 for (HYD) and (TRM), respectively. The limit of detection (LOD) and limit of quantification (LOQ) were to be 0.143 ??g/mL and 0.433 ??g/mL for (HYD), 0.128 ??g/mL and 0.390 ??g/mL for (TRM), respectively. 0.134 in table 1 The proposed derivative method was successfully applied to analysis individual or mixture of (HYD) and (TRM) in Syrian trademark drugs. All studied samples showed that the drug levels were conformed to united state pharmacopeia (USP) legislation.


Cite this article:
Saad Antakli, Leon Nejem, Ahmad Kullah. Analytical Spectrophotometric Study for Determining Hydrocholrothiazide individually or with Combination with Triametrene in some Pharmaceutical Formulations. Research J. Pharm. and Tech 2018; 11(6): 2351-2356. doi: 10.5958/0974-360X.2018.00436.5

Cite(Electronic):
Saad Antakli, Leon Nejem, Ahmad Kullah. Analytical Spectrophotometric Study for Determining Hydrocholrothiazide individually or with Combination with Triametrene in some Pharmaceutical Formulations. Research J. Pharm. and Tech 2018; 11(6): 2351-2356. doi: 10.5958/0974-360X.2018.00436.5   Available on: https://rjptonline.org/AbstractView.aspx?PID=2018-11-6-37


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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