Author(s): Kailash Sahu, Amit Alexander, Hemlata Thapa, Tripti Banjare, Palak Agrawal, Akansha Bhandarkar, Aditi Bhatt, Swapnil Gupta, Hemlata Sahu, Shradha Devi Diwedi, Pankaj Sahu, Siddharth Kumar Sahu, Pooja Yadav, Deeksha Dewangan, Deepika, Hemant Ramchandra Badwaik, Mukesh Sharma, D. K. Tripathi, Ajazuddin

Email(s): write2ajaz@gmail.com , ajazuddin@rungta.ac.in

DOI: 10.5958/0974-360X.2018.00386.4   

Address: Kailash Sahu, Amit Alexander, Hemlata Thapa, Tripti Banjare, Palak Agrawal, Akansha Bhandarkar, Aditi Bhatt, Swapnil Gupta, Hemlata Sahu, Shradha Devi Diwedi, Pankaj Sahu, Siddharth Kumar Sahu, Pooja Yadav, Deeksha Dewangan, Deepika, Hemant Ramchandra Badwaik, Mukesh Sharma, D. K. Tripathi, Ajazuddin*
Rungta College of Pharmaceutical Sciences and Research, Kohka-kurud road, Bhilai, Chhattisgarh, 4900024
*Corresponding Author

Published In:   Volume - 11,      Issue - 5,     Year - 2018


ABSTRACT:
Ziprasidone hydrochloride is a psychotropic agent. To reduce the frequency of administration and to improve patient compliance, a sustained-release formulation of Ziprasidone hydrochloride is desirable. The aim of the present work is to develop a hydrodynamically balanced drug delivery system based on the platform of direct compression. The system shall be designed to release at least 65% of the drug over a period of 8 hours and not less than 80% release in 12 hours. Sodium bicarbonate was incorporated as a gas-generating agent along with independent variables of natural resinhydroxy propyl methyl cellulose (HPMC) grade K4M and hydroxyl propyl methyl cellulose (HPMC) grade K100M at successfully prepared with hydrophilic polymers like HPMC K4M, HPMC K15M and HPMC K100M.to achieve sustained release effect. The drug-excipient compatibility was studied with the help of Infrared-red spectroscopy. Dissolution studies using the USP basket method were performed at 37±0.5ºC in 0.1N HCl and 2% SLS. Fourier transformer infrared spectroscopy (FTIR) was performed for the physicochemical interaction between drug and carrier, hence its effect on dissolution. It was observed that formulation containing 60% hydroxy propyl methyl cellulose (HPMC) grade K15M (F6) shows optimum sustained drug release pattern with adequate floating. Thus this technique can be successfully used for improvement of dissolution of ziprasidonehydrocholoride.


Cite this article:
Kailash Sahu, Amit Alexander, Hemlata Thapa, Tripti Banjare, Palak Agrawal, Akansha Bhandarkar, Aditi Bhatt, Swapnil Gupta, Hemlata Sahu, Shradha Devi Diwedi, Pankaj Sahu, Siddharth Kumar Sahu, Pooja Yadav, Deeksha Dewangan, Deepika, Hemant Ramchandra Badwaik, Mukesh Sharma, D. K. Tripathi, Ajazuddin. Formulation and Evaluation of Gastro Retentive Sustained Release Tablets of Ziprasidone Hydrochloride. Research J. Pharm. and Tech 2018; 11(5):2080-2085. doi: 10.5958/0974-360X.2018.00386.4

Cite(Electronic):
Kailash Sahu, Amit Alexander, Hemlata Thapa, Tripti Banjare, Palak Agrawal, Akansha Bhandarkar, Aditi Bhatt, Swapnil Gupta, Hemlata Sahu, Shradha Devi Diwedi, Pankaj Sahu, Siddharth Kumar Sahu, Pooja Yadav, Deeksha Dewangan, Deepika, Hemant Ramchandra Badwaik, Mukesh Sharma, D. K. Tripathi, Ajazuddin. Formulation and Evaluation of Gastro Retentive Sustained Release Tablets of Ziprasidone Hydrochloride. Research J. Pharm. and Tech 2018; 11(5):2080-2085. doi: 10.5958/0974-360X.2018.00386.4   Available on: https://rjptonline.org/AbstractView.aspx?PID=2018-11-5-71


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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