Author(s): Rajesh Kumar, Mukhyaprana Prabhu, Sreedhar R Pai, Vasudev Shenoy

Email(s): Shenoy.vasudev@gmail.com

DOI: 10.5958/0974-360X.2018.00380.3   

Address: Dr Rajesh Kumar1, Dr Mukhyaprana Prabhu2, Dr Sreedhar R Pai3, Mr. Vasudev Shenoy4*
1Dept of Nuclear Medicine, Kasturba Medical College, Manipal University, India
2Dept of Medicine, Kasturba Medical College, Manipal University, India
3Dept of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, India
4Biovailability/Bioequivalence and PK Unit, Ecron Acunova, Manipal, India
*Corresponding Author

Published In:   Volume - 11,      Issue - 5,     Year - 2018


ABSTRACT:
The current therapy for patients with thyroid cancer is total or near to total thyroidectomy with Radio Iodine treatment. Subsequent to the thyroidectomy the patients are on Levothyroxine as a supplement therapy to maintain the Thyroid hormone levels.Levothyroxine has been considered as a narrow therapeutic index drug. In Thyroid cancer patients, radio-iodine ablation procedure causes hypothyroid state which will be further elongated by the administration of sub optimal doses and hyperthyroid symptoms with higher doses. The current study was conducted to evaluate the covariates influencing the drug concentration of levothyroxine in our target population, i.e Patient with Papillary carcinoma, undergone total thyroidectomy followed by 131I ablation and on Levothyroxine.


Cite this article:
Rajesh Kumar, Mukhyaprana Prabhu, Sreedhar R Pai, Vasudev Shenoy. Evaluation of Covariates using Population Pharmacokinetics approach for dose Individualization of Levothyroxine in Patients with Post Thyroidectomy and 131I ablation Therapy. Research J. Pharm. and Tech 2018; 11(5):2050-2054. doi: 10.5958/0974-360X.2018.00380.3

Cite(Electronic):
Rajesh Kumar, Mukhyaprana Prabhu, Sreedhar R Pai, Vasudev Shenoy. Evaluation of Covariates using Population Pharmacokinetics approach for dose Individualization of Levothyroxine in Patients with Post Thyroidectomy and 131I ablation Therapy. Research J. Pharm. and Tech 2018; 11(5):2050-2054. doi: 10.5958/0974-360X.2018.00380.3   Available on: https://rjptonline.org/AbstractView.aspx?PID=2018-11-5-65


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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