Author(s): K. Ishwar Bhat, Abhishek Kumar

Email(s): abhi12bunty@gmail.com

DOI: 10.5958/0974-360X.2018.00357.8   

Address: K. Ishwar Bhat1, Abhishek Kumar2*
1Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Paneer, Deralakatte-575018, Mangalore, Karnataka.
2Assistant Professor, Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences Paneer, Deralakatte, Mangalore 575018, Karnataka, India.
*Corresponding Author

Published In:   Volume - 11,      Issue - 5,     Year - 2018


ABSTRACT:
A series of novel pyrimidine-2-thiol derivatives (PM1-PM6) have been synthesized upon refluxing 1-(4-nitrophenyl)-3-phenyl substituted prop-2-en-1-one in presence of thiourea and glacial acetic acid. 1-(4-nitrophenyl)-3-phenyl substituted prop-2-en-1-one were prepared by condensing 4-nitroacetophenone with substituted benzaldehydes in presence of 20% NaOH as base. The structures of newly synthesized compounds were characterized by IR, 1H NMR and mass spectroscopic studies. Newly synthesized compounds were screened for their antioxidant studies. Most of the compounds exhibited excellent antioxidant activity compared to the standard drug ascorbic acid.


Cite this article:
K. Ishwar Bhat, Abhishek Kumar. Pyrimidines as Potent Antioxidant Agents. Research J. Pharm. and Tech 2018; 11(5):1927-1929. doi: 10.5958/0974-360X.2018.00357.8

Cite(Electronic):
K. Ishwar Bhat, Abhishek Kumar. Pyrimidines as Potent Antioxidant Agents. Research J. Pharm. and Tech 2018; 11(5):1927-1929. doi: 10.5958/0974-360X.2018.00357.8   Available on: https://rjptonline.org/AbstractView.aspx?PID=2018-11-5-42


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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