Author(s): Hemlata Thapa, Amit Alexander, Tripti Banjare, Palak Agrawal, Akansha Bhandarkar, Aditi Bhatt, Swapnil Gupta, Hemlata Sahu, Shradha Devi Diwedi, Pankaj Sahu, Siddharth Kumar Sahu, Pooja Yadav, Kailash Sahu, Deeksha Dewangan, Deepika, Mukesh Sharma, D. K. Tripathi, Ajazuddin

Email(s): write2ajaz@gmail.com , ajazuddin@rungta.ac.in

DOI: 10.5958/0974-360X.2018.00328.1   

Address: Hemlata Thapa, Amit Alexander, Tripti Banjare, Palak Agrawal, Akansha Bhandarkar,
Aditi Bhatt, Swapnil Gupta, Hemlata Sahu, Shradha Devi Diwedi, Pankaj Sahu,
Siddharth Kumar Sahu, Pooja Yadav, Kailash Sahu, Deeksha Dewangan, Deepika,
Mukesh Sharma, D. K. Tripathi, Ajazuddin*
Rungta College of Pharmaceutical Sciences and Research, Kohka-kurud Road, Bhilai, Chhattisgarh, 4900024
*Corresponding Author

Published In:   Volume - 11,      Issue - 5,     Year - 2018


ABSTRACT:
With emergence of new technology and concept, self-poring osmotic tablets were developed in order to reduce the complications and problems associated with micro drilling and laser drilling in osmotic tablet. This research describes a very simple and cheap method of developing self-poring osmotic tablet that deliver DiltiazemHCl in a controlled rate for prolonged duration. For this purpose 5 formulations of osmotictablets were prepared through wet granulation technique in which different concentration of sodium lauryl sulphate (SLS) were used as pore forming agent in coating solution. In tablet core also varied concentration of sorbitol as osmogens, guar gum and HPMC were encorporated, which forms gel like matrix through which drug releases at zero order. Through optimization out of 5 formulations, F3 (C2) formulation was selected as best. From result of invitro drug release study it was clear that more concentration of pore former and osmogens releases drug in short time while less concentration takes more time for drug release. Therefore, it is necessary to use SLS, polymer and osmogens in balance concentration for getting optimum control release at zero order upto 24 hrs. Self-poring Osmotic tablets hold promising potential for increasing drug efficacy and reducing dosing frequency with minimal side effects also provides an economic means of developing controlled release dosage forms.


Cite this article:
Hemlata Thapa, Amit Alexander, Tripti Banjare, Palak Agrawal, Akansha Bhandarkar, Aditi Bhatt, Swapnil Gupta, Hemlata Sahu, Shradha Devi Diwedi, Pankaj Sahu, Siddharth Kumar Sahu, Pooja Yadav, Kailash Sahu, Deeksha Dewangan, Deepika, Mukesh Sharma, D. K. Tripathi, Ajazuddin . Formulation and Evaluation of Self-Poring Osmotic Tablet of Diltiazem HCl for the Treatment of Hypertension. Research J. Pharm. and Tech 2018; 11(5): 1768-1773 doi: 10.5958/0974-360X.2018.00328.1

Cite(Electronic):
Hemlata Thapa, Amit Alexander, Tripti Banjare, Palak Agrawal, Akansha Bhandarkar, Aditi Bhatt, Swapnil Gupta, Hemlata Sahu, Shradha Devi Diwedi, Pankaj Sahu, Siddharth Kumar Sahu, Pooja Yadav, Kailash Sahu, Deeksha Dewangan, Deepika, Mukesh Sharma, D. K. Tripathi, Ajazuddin . Formulation and Evaluation of Self-Poring Osmotic Tablet of Diltiazem HCl for the Treatment of Hypertension. Research J. Pharm. and Tech 2018; 11(5): 1768-1773 doi: 10.5958/0974-360X.2018.00328.1   Available on: https://rjptonline.org/AbstractView.aspx?PID=2018-11-5-12


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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