Author(s): Shaiju S. Dharan, R. Narayana Charyulu, Sandeep DS

Email(s): narayana@nitte.edu..in

DOI: 10.5958/0974-360X.2018.00271.8   

Address: Shaiju S. Dharan1, R. Narayana Charyulu2*, Sandeep DS3
1Research Scholar, Nitte (Deemed to be University), Mangalore, Karnataka, India.
2Professor and Vice Principal N. G. S. M. Institute of Pharmaceutical Sciences Nitte (Deemed to be university), Paneer, Deralakatte, Mangalore-575018.
3Assistant Professor, Department of Pharmaceutics, N.G.S.M Institute of Pharmaceutical Sciences, Nitte (Deemed to be university), Paneer, Deralakatte, Mangalore-575018.
*Corresponding Author

Published In:   Volume - 11,      Issue - 4,     Year - 2018


ABSTRACT:
The study was aimed at the formulation and evaluation of gastroretentive bilayer floating films of famotidine. A bilayer film consisting of an Immediate Release Layer (IR) and a Sustained Release Layer (SR) were prepared by solvent casting technique. The prepared films were evaluated for film thickness, percentage swelling, folding endurance, tensile strength, drug content estimation and in vitro dissolution studies. Compatibility studies using FTIR were also done for the detection of possible interaction between drug, polymer and other additives. Optimized bilayered floating films were reformulated by including barium sulphate instead of the active drug, famotidine and subjected to in vivo radiographic studies in New Zealand white rabbits in order to confirm the gastric retention.


Cite this article:
Shaiju S. Dharan, R. Narayana Charyulu, Sandeep DS. Formulation and Evaluation of Gastroretentive Bilayered Floating Films of Famotidine: Effect of Formulation variables and in Vitro in Vivo Evaluation. Research J. Pharm. and Tech 2018; 11(4): 1452-1460. doi: 10.5958/0974-360X.2018.00271.8


Recomonded Articles:

Author(s): Jayesh M Jain, Dinesh M Sakarkar, Shajahan Abdul, Mangesh E Bhad, Anil V Chandewar and Sunil B Jaiswal

DOI: Not Available         Access: Closed Access Read More

Author(s): Mohammed Ehtesham Ur Rahman, Mohammed Abdul Haseeb, Mohammed Saleem, Abdul Naveed

DOI: Not Available         Access: Open Access Read More

Author(s): K. Gnanaprakash, K.B. Chandhra Shekhar, C. Madhu Sudhana Chetty

DOI: Not Available         Access: Open Access Read More

Author(s): R.V Rele, J.M. Parab, V.V. Mhatre, C.B. Warkar

DOI: Not Available         Access: Open Access Read More

Author(s): Lalit Singh, Arun Nanda, Bhupinder Singh, Saurabh Sharma

DOI: Not Available         Access: Open Access Read More

Author(s): Kute Chaitrali, Dev Asish, Rathod Sudha, Qureshi Altamash

DOI: Not Available         Access: Open Access Read More

Author(s): Jaideep Singh, Shivalinge Gowda KP, Shrishailappa Badami, Rahul Akuskar, Nagarjan Tukuru

DOI:         Access: Open Access Read More

Author(s): Mridanga Raj Ray, Sekhar Kumar Bose, Koushik Sengupta

DOI:         Access: Open Access Read More

Author(s): Wrushali A. Panchale, Rajnandini Suroshe, Minakshi S. Rathod, Yuvraj L. Pandhare

DOI: 10.5958/0974-360X.2019.00043.X         Access: Closed Access Read More

Author(s): Senthil. S.P, Sreeja. M.K, Jerin Vincent, Manoj Kumar Singh

DOI: Not Available         Access: Open Access Read More

Author(s): Nayak Bhabani Shankar, Nayak Udaya Kumar, Patro K Balakrishna, Rout Prasant Kumar

DOI:         Access: Open Access Read More

Author(s): Rajashree S Masareddy, Smitha D Rananaware, Bhushan R Patil

DOI: Not Available         Access: Open Access Read More

Author(s): Chandrashekar Patil, Kousarbanu Indikar, Bhaskar Umarji

DOI: DOI: 10.5958/0974-360X.2015.00003.7         Access: Open Access Read More

Author(s): Saripilli Rajeswari, Koralla Hari, K. V. Ramana Murthy

DOI: 10.5958/0974-360X.2019.00250.6         Access: Closed Access Read More

Author(s): Karpe Manisha S., Kadam Vilasrao J.

DOI: 10.5958/0974-360X.2015.00002.5         Access: Open Access Read More

Author(s): Pavan Suradkar, Rakesh Mishra, Tanaji Nandgude

DOI: 10.5958/0974-360X.2019.00975.2         Access: Closed Access Read More

Author(s): Akelesh T, Venkidesh Rajagopal, Sam Johnson Udaya Chander J, Manavalan R, Venkatanarayanan R

DOI: 10.5958/0974-360X.2016.00440.6         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags