Studies of human behavioral genetics have made it easier to understand the relative contributions of genetics and the environment in observed variation in human behavior. The genes responsible for the aggressive behavior with the help of literary works along with the proteins they code were identified and the functions of these proteins and the pathways in which they are involved are also identified. According to the functions of these receptors it is observed that over expression of 2 main receptors lead to abnormal and increased aggression. This means inhibiting this over expression would be a source of solution to reduce this abnormal behavior. Therefore ligands are selected from GeneCards and Malacards based on their inhibiting properties which can act as antipsychotic agents, dopamine antagonists, serotonin antagonist and antidepressants. These ligands are then screened based on the ADMET properties. The results show that ligands such as L-tyrosine, dexmethylphenidate, olanzapine, parozetine, selegiline and loxapine are more favorable to bind with the proteins. These ligands are then docked with the receptors to find the appropriate inhibitors. The interaction between the receptors and the ligands are studied, the docking study reveals that the appropriate ligands can be used as a solution for aggressive, criminal and violent behavioral changes as it helps to retain the normal behavior.
Cite this article:
Balasankar Karavadi, Martina V. Insilico Analysis of Inhibitors Related to Aggressive Behavior in Human Beings. Research J. Pharm. and Tech 2018; 11(4): 1436-1441. doi: 10.5958/0974-360X.2018.00268.8