Author(s): Swapnil Gupta, Ajazuddin, Pooja Yadav, Hemlata Thapa, Tripti Banjare, Palak Agrawal, Akansha Bhandarkar, Aditi Bhatt, Hemlata Sahu, Shradha Devi Diwedi, Pankaj Sahu, Siddharth Kumar Sahu, Kailash Sahu, Deeksha Dewangan, Deepika, Mukesh Sharma, D. K. Tripathi, Amit Alexander

Email(s): write2ajaz@gmail.com , ajazuddin@rungta.ac.in

DOI: 10.5958/0974-360X.2018.00220.2   

Address: Swapnil Gupta, Ajazuddin*, Pooja Yadav, Hemlata Thapa, Tripti Banjare, Palak Agrawal, Akansha Bhandarkar, Aditi Bhatt, Hemlata Sahu, Shradha Devi Diwedi, Pankaj Sahu, Siddharth Kumar Sahu, Kailash Sahu, Deeksha Dewangan, Deepika, Mukesh Sharma, D. K. Tripathi, Amit Alexander
Rungta College of Pharmaceutical Sciences and Research, Kohka-kurud road, Bhilai, Chhattisgarh, 4900024
*Corresponding Author

Published In:   Volume - 11,      Issue - 3,     Year - 2018


ABSTRACT:
The aim of present research was to report the buccoadhesive tablet of itraconazole to provide localized delivery of drug for the treatment of oral thrush and maintain the drug concentration in the mouth for prolonged period of time thereby improving the oral bioavailability of drug. Buccoadhesive tablet is a sustained release of itraconazole for easy permeation across buccal mucosa and provide a local delivery concentration that may or may not be sufficient to maintain MIC to kill the microorganism. Solid dispersion of itraconazole was prepared by solvent evaporation technique using silica gel act as adsorbent and drug was soluble in chloroform to obtain a slurry or uniform mixture. The buccoadhesive tablet was prepared by direct compression method using different polymers such as Carbopol(C934P),HPMC K4M, Eudragit E100. Five formulations of different concentrations were prepared. Itraconazole strength were kept constant at 30mg and target was fixed at 120mg. After examine the moisture content, bulk density, tapped density, Angle of repose of powder blend get the result were found to be prescribed limit and indicated good flow property. Then the tablets were evaluated for hardness, thickness, weight variation, drug content, friability, swelling index, In-vitro drug release.


Cite this article:
Swapnil Gupta, Ajazuddin, Pooja Yadav, Hemlata Thapa, Tripti Banjare, Palak Agrawal, Akansha Bhandarkar, Aditi Bhatt, Hemlata Sahu, Shradha Devi Diwedi, Pankaj Sahu, Siddharth Kumar Sahu, Kailash Sahu, Deeksha Dewangan, Deepika, Mukesh Sharma, D. K. Tripathi, Amit Alexander . Formulation and evaluation of sustained released buccoadhesive tablets of Itraconazole. Research J. Pharm. and Tech. 2018; 11(3): 1179-1184. doi: 10.5958/0974-360X.2018.00220.2

Cite(Electronic):
Swapnil Gupta, Ajazuddin, Pooja Yadav, Hemlata Thapa, Tripti Banjare, Palak Agrawal, Akansha Bhandarkar, Aditi Bhatt, Hemlata Sahu, Shradha Devi Diwedi, Pankaj Sahu, Siddharth Kumar Sahu, Kailash Sahu, Deeksha Dewangan, Deepika, Mukesh Sharma, D. K. Tripathi, Amit Alexander . Formulation and evaluation of sustained released buccoadhesive tablets of Itraconazole. Research J. Pharm. and Tech. 2018; 11(3): 1179-1184. doi: 10.5958/0974-360X.2018.00220.2   Available on: https://rjptonline.org/AbstractView.aspx?PID=2018-11-3-67


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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