Author(s): Shradha Devi Diwedi, Amit Alexander, Deepika, Palak Agrawal, Tripti Banjare, Swapnil Gupta, Hemlata Sahu, Siddharth Kumar Sahu, Pooja Yadav, Kailash Sahu, Aditi Bhatt, Deeksha Dewangan, Hemlata Thapa, Pankaj Sahu, Kushagra Nagori, Ajay Singh, Mukesh Sharma, D. K. Tripathi, Ajazuddin

Email(s): write2ajaz@gmail.com , ajazuddin@rungta.ac.in

DOI: 10.5958/0974-360X.2018.00213.5   

Address: Shradha Devi Diwedi1, Amit Alexander1, Deepika1, Palak Agrawal1, Tripti Banjare1, Swapnil Gupta1, Hemlata Sahu1, Siddharth Kumar Sahu1, Pooja Yadav1, Kailash Sahu1, Aditi Bhatt1, Deeksha Dewangan1, Hemlata Thapa1, Pankaj Sahu1, Kushagra Nagori1, Ajay Singh2, Mukesh Sharma1, D. K. Tripathi1, Ajazuddin1*
1Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai, Chhattisgarh, 4900024
2GD Rungta College of Science and Technology, Kohka-Kurud Road, Bhilai, Chhattisgarh, 4900024
*Corresponding Author

Published In:   Volume - 11,      Issue - 3,     Year - 2018


ABSTRACT:
The aim of this research was to prepare and evaluate sustain release mucoadhesive tablet ofitraconazole, in order to overcome its poor biopharmaceutical property and therapeutical efficacy.Itraconazole have low aqueous solubility and high permeability, hence in order to improve its solubility in both HCl and water it is formulated as solid dispersion by using solvent evaporation method.Solid dispersion was formulated using with itraconazolePEG 6000in the ratio of 1:2. Solid dispersion was then formulated in matrix of hydrophilic mucoadhesive polymers Carbopol 934P (CP) and HPMC E5LV into mucoadhesive sustained release tablet. Further,formulation were optimized for various amounts of CP and HPMC. Various amount of HPMC and Carbapol were taken as formulation variables for optimizing response variables i.e. dissolution parameters. Solid dispersion leads to enhancement in solubility of itraconazole in water up to 5.95% and in HCl it was 6.43%. In addition to enhancement of solubility in HCl and water they also lead to the slow release of drug up to 1.44% in 1 hour.Optimum combination of mucoadhesive polymers Carbopol 934P (CP) and HPMC E5LV provided adequate fairly regulated release profile. The experimental and predicted results for optimum formulations were found to be in close agreement. The formulation showed percentage drug release upto 86% for 9hour.


Cite this article:
Shradha Devi Diwedi, Amit Alexander, Deepika, Palak Agrawal, Tripti Banjare, Swapnil Gupta, Hemlata Sahu, Siddharth Kumar Sahu, Pooja Yadav, Kailash Sahu, Aditi Bhatt, eeksha Dewangan, Hemlata Thapa, Pankaj Sahu, Kushagra Nagori, Ajay Singh, Mukesh Sharma, D. K. Tripathi, Ajazuddin. Formulation and evaluation of Itraconazole ucoadhesive tablets for sustained release. Research J. Pharm. and Tech. 2018; 11(3): 1140-1146. doi: 10.5958/0974-360X.2018.00213.5

Cite(Electronic):
Shradha Devi Diwedi, Amit Alexander, Deepika, Palak Agrawal, Tripti Banjare, Swapnil Gupta, Hemlata Sahu, Siddharth Kumar Sahu, Pooja Yadav, Kailash Sahu, Aditi Bhatt, eeksha Dewangan, Hemlata Thapa, Pankaj Sahu, Kushagra Nagori, Ajay Singh, Mukesh Sharma, D. K. Tripathi, Ajazuddin. Formulation and evaluation of Itraconazole ucoadhesive tablets for sustained release. Research J. Pharm. and Tech. 2018; 11(3): 1140-1146. doi: 10.5958/0974-360X.2018.00213.5   Available on: https://rjptonline.org/AbstractView.aspx?PID=2018-11-3-60


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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