Author(s): Hadi F. Alyasari, Jawad K. T. Al-khafaji, Hayam Khalis Al-Masoud

Email(s): hadialyasari@gmail.com

DOI: 10.5958/0974-360X.2018.00200.7   

Address: Hadi F. Alyasari, Jawad K. T. Al-khafaji, Hayam Khalis Al-Masoudi
Microbiology, College of Medicine/University of Babylon, Iraq
*Corresponding Author

Published In:   Volume - 11,      Issue - 3,     Year - 2018


ABSTRACT:
Since various and numerous pathogenic microorganisms can infect and dwell human's urogenital tract, and because the ability of bacteria to develop resistance to antibiotics, in addition to the side effects of some of these antibiotics in treatment of infectious diseases, therefore we need to alternative herbal and non-antibiotic therapy for treating the urogenital tract infections such as Garlic (Allium sativum L.). The aim of the study is to investigate the antimicrobial effects of Garlic extract on local uropathogenic species of Escherichia coli, Proteus mirabilis and Trichomonas vaginalis in cases of urogenital tract infections. The tested urogenital microorganisms were isolated and identified according to diagnostic features as golden of morphology and biophysiology for Escherichia coli, Proteus mirabilis and Trichomonas vaginalis. Fresh garlic bulbs were obtained from local markets of Iraq. The aqueous garlic extract (AGE) was performed according to standard method. The antibacterial activity of AGE was done against motility, adherence and biofilm formation, and compared with some UTI antibiotics. The antiparasitic activity of AGE was done against growth rate, motility and viability of cultured vaginalis in vitro by use medium. current study suggest that the AGE has antibacterial effects against E. coli and Pr. mirabilis. The diameter of the inhibition zone was ranged from 27.0 to 28.0 mm for garlic extract, as compared with 12.0 to 18.0 mm for Ciprofloxacin against both genera; E. coli and Proteus mirabilis, respectively. The efficacy of adherence and biofilm formation by E. coli and Pr. Mirabilis was much reduced. The motility of these bacteria was completely inhibited following AGE exposure to 30%, and temporally inhibited by 20%. Furthermore, the growth rate, viability and motility of the studied protozoan parasite " vaginalis" were completely inhibited following exposure to crude extract of AGE post 1 hour, completely inhibited following AGE exposure of 30% post 24 hour, completely inhibited by 20% post 48 hour, completely inhibited by 10% post 72 hour and temporally inhibited by 5% post 96 hour, respectively.


Cite this article:
Hadi F. Alyasari, Jawad K. T. Al-khafaji, Hayam Khalis Al-Masoud. Inhibitory effects of Garlic extract on uropathogenic Escherichia coli; Proteus mirabilis and Trichomonas vaginalis isolated from urogenital tract cases. Research J. Pharm. and Tech. 2018; 11(3): 1071-1077. doi: 10.5958/0974-360X.2018.00200.7


Recomonded Articles:

Author(s): Umesh Kumar, Rakesh Narang, Surendra Kumar Nayak, Sachin Kumar Singh, Vivek Gupta

DOI: 10.5958/0974-360X.2017.00425.5         Access: Open Access Read More

Author(s): Niharika, Navneet Verma

DOI: 10.5958/0974-360X.2016.00182.7         Access: Open Access Read More

Author(s): A. S. K. Sankar, B. Datchayani, N. Balakumaran, Mohammed Rilwan, R. Subaranjani

DOI: 10.5958/0974-360X.2017.00047.6         Access: Open Access Read More

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): Raj Kumar R, Praveen D, Palani Shanmugasundaram

DOI: 10.5958/0974-360X.2016.00164.5         Access: Open Access Read More

Author(s): Aadil Ahamed.S, Dhanraj. M

DOI: 10.5958/0974-360X.2017.00169.X         Access: Open Access Read More

Author(s): Sandeep D. S, Prashant Nayak, Jobin Jose, Rishal Relita M, Sumana D. R.

DOI: 10.5958/0974-360X.2017.00317.1         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Leelavathi D Acharya, N R Rau, N Udupa, Surulivel Rajan M, Vijayanarayana K

DOI: 10.5958/0974-360X.2016.00162.1         Access: Open Access Read More

Author(s): H. Firdus Fareen, M.S. Thenmozhi

DOI: 10.5958/0974-360X.2016.00146.3         Access: Open Access Read More

Author(s): M. Sumithra, Avantika Prabhabanik

DOI: 10.5958/0974-360X.2017.00036.1         Access: Open Access Read More

Author(s): Vandana Gautam, Dhriti Kapoor, Saroj Arora, Renu Bhardwaj*

DOI: 10.5958/0974-360X.2016.00166.9         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags