Author(s): Shashikant Chandrakar, Amit Roy, Ram Sahu

Email(s): shashikant.py@gmail.com

DOI: 10.5958/0974-360X.2018.00192.0   

Address: Shashikant Chandrakar *, Amit Roy, Ram Sahu
Columbia Institute of Pharmacy, Raipur (C.G.) 493111 India
*Corresponding Author

Published In:   Volume - 11,      Issue - 3,     Year - 2018


ABSTRACT:
Ciprofloxacin hydrochloride is water soluble fluoroquinolone derivative antibacterial agent used for bacterial infection in the eye. It is also available in market as eye drop in aqueous solution. The problem with aqueous solution is that it shoes low permeability and requires frequent doing due washing action and blinking reflex in the eye. To overcome this problem microemulsion were prepared. The aim of present study was to develop and evaluates microemulsion of Ciprofloxacin hydrochloride for ocular delivery of drug. Pseudoternaty phase diagram was prepared by using span 80, tween 20 as mixed surfactant, sesame oil as oil phase and double distilled water as aqueous media. The nine microemulsion (M1 to M9) were prepared and evaluated for globule size, zeta potential, polydispersity index, percentage drug content, viscosity, conductivity, percentage transmittance and pH.The globule size of M1 to M9 was in the range 116.6±0.07 to 278.4±0.06 nm. The zeta potential values ranged between +11.23±0.11and +24.56±0.17 mV. The PDI value shows narrow size distribution of globule. The drug content of microemulsion varies from 98.12±0.37% to 99.54± 0.36%.The viscosity value for the microemulsion was found <20 cp. The conductivity values from 0.011±0.18to 0.042±0.62.The percentage transmittance of microemulsion varies from 97.1±0.15% to 99.8±0.11 %. The pH values of microemulsions were found acceptable for ocular application. From the size analyses it was observed that microemulsion M1 to M6 showing narrow size range (<200 nm) and it was selected for further study.


Cite this article:
Shashikant Chandrakar, Amit Roy, Ram Sahu. Phase behavior study of Ciprofloxacin hydrochloride Microemulsion prepared by mixed Nonionic surfactant. Research J. Pharm. and Tech. 2018; 11(3): 1030-1034. doi: 10.5958/0974-360X.2018.00192.0


Recomonded Articles:

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Kumkum Sarangdevot, Bhawani Singh Sonigara, Amul Mishra, K. C. Gupta, Surbhi Sharma

DOI: Not Available         Access: Open Access Read More

Author(s): Samiksha Warke, Prashant Warke, M.K. Kale, Vipin Saini

DOI: Not Available         Access: Open Access Read More

Author(s): Benly P.

DOI: Not Available         Access: Open Access Read More

Author(s): Sumit Yadav, Kawtikwar PS, Sakarkar DM, Gholse YN, Ghajbhiye SD

DOI:         Access: Open Access Read More

Author(s): Subhashis Debnath1*, Gampa Vijay Kumar2, Satayanarayana S.V.3

DOI: Not Available         Access: Open Access Read More

Author(s): Sudha Rathod, Tejaswi R. Kale, Deepali A. Shewale, Praveen N. Lohar

DOI: Not Available         Access: Open Access Read More

Author(s): Atul Arvind Bodkhe, Ramandeep Singh Bedi, Ashutosh Upadhayay, Mohan K. Kale

DOI: 10.5958/0974-360X.2018.00998.8         Access: Open Access Read More

Author(s): P. Raghuveer, J. Vanithakamal, D. Madhuri, A. Prameela Rani

DOI: 10.5958/0974-360X.2018.00221.4         Access: Open Access Read More

Author(s): Retneswari Masilamani, Myat Moe Thwe Aung, Vidya Bhagat, Aini Abu Bakar, Tung Him Soon, Lim Chee Yao, Ng Jia Hui, Low Zhen Ning

DOI: 10.5958/0974-360X.2018.00543.7         Access: Open Access Read More

Author(s): Janani SK, R. Suresh Kumar, Chenmala Karthika, Vasanthi C, Shaik Rafi Kapoor

DOI: 10.5958/0974-360X.2019.00543.2         Access: Open Access Read More

Author(s): Dhruti P. Mehta, Hemendrasinh J. Rathod, Dhiren P. Shah, Chainesh N. Shah

DOI: 10.5958/0974-360X.2015.00021.9         Access: Open Access Read More

Author(s): Deep Shikha Sharma, Amritpal Kaur, Sheetu Wadhwa, Sachin Kumar Singh, Rajesh Kumar, Rubia Khursheed, Arya Ramanunny

DOI: 10.5958/0974-360X.2019.00789.3         Access: Open Access Read More

Author(s): Akiladevi D, Hari Prakash, Biju Gb, Madumitha N

DOI: 10.5958/0974-360X.2020.00183.3         Access: Closed Access Read More

Author(s): Sayani Bhattacharyya, Hemant Adhikari, Durgaprasad Regmi

DOI: 10.5958/0974-360X.2019.00699.1         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags