Ciprofloxacin hydrochloride is water soluble fluoroquinolone derivative antibacterial agent used for bacterial infection in the eye. It is also available in market as eye drop in aqueous solution. The problem with aqueous solution is that it shoes low permeability and requires frequent doing due washing action and blinking reflex in the eye. To overcome this problem microemulsion were prepared. The aim of present study was to develop and evaluates microemulsion of Ciprofloxacin hydrochloride for ocular delivery of drug. Pseudoternaty phase diagram was prepared by using span 80, tween 20 as mixed surfactant, sesame oil as oil phase and double distilled water as aqueous media. The nine microemulsion (M1 to M9) were prepared and evaluated for globule size, zeta potential, polydispersity index, percentage drug content, viscosity, conductivity, percentage transmittance and pH.The globule size of M1 to M9 was in the range 116.6±0.07 to 278.4±0.06 nm. The zeta potential values ranged between +11.23±0.11and +24.56±0.17 mV. The PDI value shows narrow size distribution of globule. The drug content of microemulsion varies from 98.12±0.37% to 99.54± 0.36%.The viscosity value for the microemulsion was found <20 cp. The conductivity values from 0.011±0.18to 0.042±0.62.The percentage transmittance of microemulsion varies from 97.1±0.15% to 99.8±0.11 %. The pH values of microemulsions were found acceptable for ocular application. From the size analyses it was observed that microemulsion M1 to M6 showing narrow size range (<200 nm) and it was selected for further study.
Cite this article:
Shashikant Chandrakar, Amit Roy, Ram Sahu. Phase behavior study of Ciprofloxacin hydrochloride Microemulsion prepared by mixed Nonionic surfactant. Research J. Pharm. and Tech. 2018; 11(3): 1030-1034. doi: 10.5958/0974-360X.2018.00192.0