Author(s): Shaikh Siraj Nawaj, Mujahid Khan, G. J. Khan, Aamir Sohel

Email(s): sirajsk1234@gmail.com

DOI: 10.5958/0974-360X.2018.00171.3   

Address: Dr Shaikh Siraj Nawaj1*, Mujahid Khan2, Dr G. J. Khan2, Aamir Sohel2
1Head Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra,India.
2Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India
*Corresponding Author

Published In:   Volume - 11,      Issue - 3,     Year - 2018


ABSTRACT:
The purpose of the present work was to design and optimize compression coated floating pulsatile drug delivery systems of Bisoprolol fumarate as an antihypertensive agent . The prepared system consisted of two parts: a core tablet containing the active ingredient and an erodible outer shell with gas generating agent. The rapid release core tablet (RRCT) was prepared by using super disintegrates with active ingredient. Press coating of optimized RRCT was done by polymer. A 32full factorial design was used for optimization. The amount of HPMC K200M and Avicel pH 102 was selected as independent variables. Lag time and hardness were selected as dependent variables. Floating pulsatile release formulation (FPRT) F2 at level +1 (100mg) for HPMC K200M and level -1 (20mg) for Avicel pH 102 showed lag time of 6 h with >90% drug release. The data were statistically analyzed using ANOVA, and ??< 0.0001 was statistically significant.


Cite this article:
Shaikh Siraj Nawaj, Mujahid Khan, G. J. Khan, Aamir Sohel. Design, Development and Evaluation of Press Coated Floating Pulsatile Tablet of Antihypertensive Agent. Research J. Pharm. and Tech. 2018; 11(3): 921-929. doi: 10.5958/0974-360X.2018.00171.3


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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