Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Design, Development and Evaluation of Press Coated Floating Pulsatile Tablet of Antihypertensive Agent

Author(s): Shaikh Siraj Nawaj, Mujahid Khan, G. J. Khan, Aamir Sohel

Email(s): sirajsk1234@gmail.com

DOI: 10.5958/0974-360X.2018.00171.3   

Address: Dr Shaikh Siraj Nawaj1*, Mujahid Khan2, Dr G. J. Khan2, Aamir Sohel2
1Head Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra,India.
2Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India
*Corresponding Author

Published In:   Volume - 11,      Issue - 3,     Year - 2018

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ABSTRACT:
The purpose of the present work was to design and optimize compression coated floating pulsatile drug delivery systems of Bisoprolol fumarate as an antihypertensive agent . The prepared system consisted of two parts: a core tablet containing the active ingredient and an erodible outer shell with gas generating agent. The rapid release core tablet (RRCT) was prepared by using super disintegrates with active ingredient. Press coating of optimized RRCT was done by polymer. A 32full factorial design was used for optimization. The amount of HPMC K200M and Avicel pH 102 was selected as independent variables. Lag time and hardness were selected as dependent variables. Floating pulsatile release formulation (FPRT) F2 at level +1 (100mg) for HPMC K200M and level -1 (20mg) for Avicel pH 102 showed lag time of 6 h with >90% drug release. The data were statistically analyzed using ANOVA, and ??< 0.0001 was statistically significant.


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Cite this article:
Shaikh Siraj Nawaj, Mujahid Khan, G. J. Khan, Aamir Sohel. Design, Development and Evaluation of Press Coated Floating Pulsatile Tablet of Antihypertensive Agent. Research J. Pharm. and Tech. 2018; 11(3): 921-929. doi: 10.5958/0974-360X.2018.00171.3


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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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