Author(s): Priyanka M. Pandya, Pankaj P. Kapupara, Ketan V. Shah

Email(s): ketan.shah@rku.ac.in

DOI: 10.5958/0974-360X.2018.00165.8   

Address: Priyanka M. Pandya, Pankaj P. Kapupara, Ketan V. Shah*
School of Pharmacy, R K University, Kasturbadham, Rajkot, Gujarat, India-360020 *Corresponding Author

Published In:   Volume - 11,      Issue - 3,     Year - 2018


ABSTRACT:
A simple, efficient and reproducible method for the simultaneous determination of Clotrimazole and its Impurity (2-Chlorphenyl diphenyl methanol) has been developed using reversed phase high performance liquid chromatography. The separation was carried out using a mobile phase consisting of methanol: acetonitrile (95:5 % v/v). Column used was Zorbax C18 (100 × 4.6 mm internal diameter) 3.5 µm with flow rate of 1 ml/min. The detection wavelength used was 225 nm. The retention time of Clotrimazole and 2-Chlorophenyl diphenyl methanol were 2.81 and 2.14 respectively. Linearity of Clotrimazole and its Impurity are in range of 10-80 µg/mL and 2-12 µg/mL respectively. Analytical parameters were calculated and a statistical evaluation included.


Cite this article:
Priyanka M. Pandya, Pankaj P. Kapupara, Ketan V. Shah. Development and Validation of an Analytical Method for Simultaneous Estimation of Clotrimazole and its Impurity by RP-HPLC. Research J. Pharm. and Tech. 2018; 11(3): 894-898. doi: 10.5958/0974-360X.2018.00165.8


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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