Author(s): C. Maheswari, Abdul Mohsen Alrohimi, Amany Tawfik, Vanathi Meenashi, Zafer Saad

Email(s): maki3kp@gmail.com

DOI: 10.5958/0974-360X.2018.00154.3   

Address: Dr C. Maheswari1, Dr Abdul Mohsen Alrohimi2, Dr Amany Tawfik3, Dr Vanathi Meenashi4 Dr Zafer Saad5
1Asst Professor in Pharmacy Practice College of Pharmacy-Female Sector Shaqra University, Al-Dawadmi Kingdom of Saudi Arabia
2College of Pharmacy-Male Sector Shaqra University, Al-Dawadmi Kingdom of Saudi Arabia.
3Asst Professor in Pharmacy Practice College of Pharmacy-Male Sector Shaqra University, Al-Dawadmi Kingdom of Saudi Arabia
4 Lecturer, College of Pharmacy- Female Sector Shaqra University, Al-Dawadmi Kingdom of Saudi Arabia
5 Dean, College of Pharmacy, Shaqra University, Al-Dawadmi Kingdom of Saudi Arabia.
*Corresponding Author

Published In:   Volume - 11,      Issue - 3,     Year - 2018


ABSTRACT:
To evaluate the Insilico docking study of the compounds identified from the leaves of Orthosiphon stamieus for Hepatoprotective activity. In the present study, in-silico docking analysis was carried out for the compounds present in leaves of Orthosiphon stamineus in comparison with standard Silymarin against Pregnene X receptor and NF-?b Receptor. Experiments were performed using the program GLIDE (Grid-based Ligand Docking with Energetic) module version 5.9, Schrödinger, LLC, New York, NY, 2013 (Schrodinger Inc.). Compounds 1,2 and 4 have shown significant Pregnene X receptor inhibitory activity. Of the 3 compounds, compounds 1 and 4 showed maximum Pregnene X receptor inhibition than compound 2 and standard drug Silymarin. Compounds 1,4 and 7 have shown significant NF-?b Receptor inhibitory activity. Of the 3 compounds , compounds 1 and 4 showed maximum NF-?b Receptor inhibition than the compound 2 and the standard drug Silymarin. The study showed that the leaves of Orthosiphon stamineus is potential for the hepatoprotective activity by inhibiting Pregnene X receptor( PXR) and Nuclear Factor kappalight- chain-enhancer of activated b cells ( NF-?b Receptor)


Cite this article:
C. Maheswari, Abdul Mohsen Alrohimi, Amany Tawfik, Vanathi Meenashi, Zafer Saad. Insilico Docking Study of the Compounds Identified from the leaves of Orthosiphon stamineus for Hepatoprotective activity. Research J. Pharm. and Tech. 2018; 11(3): 829-835. doi: 10.5958/0974-360X.2018.00154.3

Cite(Electronic):
C. Maheswari, Abdul Mohsen Alrohimi, Amany Tawfik, Vanathi Meenashi, Zafer Saad. Insilico Docking Study of the Compounds Identified from the leaves of Orthosiphon stamineus for Hepatoprotective activity. Research J. Pharm. and Tech. 2018; 11(3): 829-835. doi: 10.5958/0974-360X.2018.00154.3   Available on: https://rjptonline.org/AbstractView.aspx?PID=2018-11-3-1


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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