ABSTRACT:
A herbal formulation Triphala Guggulu was prepared based on the method described in Ayurvedic Formulary of India. It contains This triphala guggulu includes Amla (Emblica officinalis), Bibhitaki (Terminalia Bellerica), Haritaki (Terminalia Chebula), Pippali (piper longum), Guggulu (Commiphora mukul) plants. Maximum plant was used in preparation of ayurvedic formulation shows anti inflammatory activities and formulation also use for treatment of inflammation and in arthritis.The aqueous extract of TG exhibited a maximum hyaluronidase enzyme inhibition of 83.90% and marketed formulations TG-1,TG-2 and TG-3 exhibit maximum maximum hyaluronidase enzyme inhibition of 83.86%,83.87% and83.89% respectively. The results of this study suggest that the Hyaluronidase enzyme inhibition of Triphala Guggulu may explain its use in joints related problems like Rheumatoid arthritis, Gout and in inflammation of joints.