Author(s): Garlapati Manideep, Nazare Lobo John Shane, Girish Pai, Muddukrishna Badamane Sathyanarayana

Email(s): gmanideep.manideep@gmail.com , krishna.mbs@manipal.edu.

DOI: 10.5958/0974-360X.2018.00142.7   

Address: Garlapati Manideep1, Nazare Lobo John Shane1, Girish Pai2, Muddukrishna Badamane Sathyanarayana1*
¹Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences (MCOPS), Manipal Academy of Higher Education, Manipal, Karnataka, India.
2Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences (MCOPS), Manipal Academy of Higher Education, Manipal, Karnataka, India.
*Corresponding Author

Published In:   Volume - 11,      Issue - 2,     Year - 2018


ABSTRACT:
This present UV Spectrophotometric method developed using methanol as a solvent is simple, rapid, specific, precise and sensitive to estimation Etoricoxib in bulk in day to day analysis. The method was validated as per ICH Q2R1 guideline. Etoricoxib is the newest addition to the group of Non-Steroidal Anti-Inflammatory Drugs - highly selective COX-2 inhibitor. The solvent used in the entire method development and validation was methanol. The maximum wavelength of absorption was found to be 234nm. Beer’s law was obeyed in the concentration range of 1 to 11µg/mL with correlation coefficient of 0.9986. The method was precise with an RSD of0.42%the LOD and LOQ were found to be 0.09µg/ml and 0.2µg/ml respectively. The method was validated for precision, linearity, accuracy and robustness and all parameters were found to be satisfactory which proves that this method can be used for routine analysis of Etoricoxib.


Cite this article:
Garlapati Manideep, Nazare Lobo John Shane, Girish Pai, Muddukrishna Badamane Sathyanarayana. Development and Validation of A UV Spectroscopic Method to Estimate Etoricoxib in Bulk and Tablet Formulation. Research J. Pharm. and Tech 2018; 11(2):758-760. doi: 10.5958/0974-360X.2018.00142.7


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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