Author(s):
Udhaya Lavinya B., Sangeetha N., Manisha P., Ramkumar K., Kavitha M., Evan Prince Sabina
Email(s):
eps674@gmail.com
DOI:
10.5958/0974-360X.2018.00141.5 
Address:
Udhaya Lavinya B., Sangeetha N., Manisha P., Ramkumar K., Kavitha M.,
Evan Prince Sabina*
School of Biosciences and Technology, VIT University, Vellore-632014, Tamilnadu, India.
*Corresponding Author
Published In:
Volume - 11,
Issue - 2,
Year - 2018
ABSTRACT:
Peptidyl arginine deaminase type 4 (PADI4) has been identified as a potential therapeutic target for rheumatoid arthritis. The aim of current study was to screen 20 chosen flavonoids for PADI4 (PDB Id.: 4X8C) inhibiting potential. The compounds were docked using PatchDock online server for molecular docking. The docked complex was visualized and the interacting patterns were analysed using PyMol software. The results revealed that compounds such as bacopaside II and X, canthaxanthine and broussonol E showed significant interaction with 4X8C with docking scores of 7864, 8432, 7962 and 8544. The study shows binding and interaction patterns of the chosen flavonoids with 4X8C. However, these compounds need to be explored for anti-arthritic activity.
Cite this article:
Udhaya Lavinya B., Sangeetha N., Manisha P., Ramkumar K., Kavitha M., Evan Prince Sabina. Virtual Screening of Peptidyl Arginine Deiminase Type 4 Inhibiting Potential of Chosen Flavonoids. Research J. Pharm. and Tech 2018; 11(2):753-757. doi: 10.5958/0974-360X.2018.00141.5
Cite(Electronic):
Udhaya Lavinya B., Sangeetha N., Manisha P., Ramkumar K., Kavitha M., Evan Prince Sabina. Virtual Screening of Peptidyl Arginine Deiminase Type 4 Inhibiting Potential of Chosen Flavonoids. Research J. Pharm. and Tech 2018; 11(2):753-757. doi: 10.5958/0974-360X.2018.00141.5 Available on: https://rjptonline.org/AbstractView.aspx?PID=2018-11-2-63