ABSTRACT:
Adhesiveness, as well as permeation of drug presents a significant challenge for the acceptability of transdermal patches. The current investigation deals with the development of pressure-sensitive based drug in transdermal patches containing Carvedilol with four different grades of acrylic polymer Duro-Tak 87- 4098, Duro-Tak 387-2051, Duro-Tak 387-2052 and Duro-Tak 87-2510 (a pressure-sensitive adhesive). Despite of the functionality or non functionality of these polymers, an attempt has been made to increase their permeability by using three distinct permeation enhancer individually, non ionic surfactant Span 80,oleic acid and a terpene farnesol. Transdermal patches containing Carvedilol were prepared by spreading method by using a fixed concentration of various grades of acrylic polymer; drug and penetration enhancers. The patches were evaluated for different physical parameters with Ex-vivo permeation studies. Skin irritation studies are conducted by using Albino Rats. Ex-vivo permeation across excised rat skin from these formulated carvedilol patches were found to be sustained over 12 h and followed the zero-order model with Fickian diffusion mechanism. The effect of permeation enhancers was in order: Span 80> farnesol >oleic acid. The skin irritation test demonstrated absence of any sign of skin irritation.