ABSTRACT:
Human cytomegalovirus (HCMV) is the most common reason of congenital infection and abortion in gestated women. Fifty women with RSA proved with CMV infection as well as 30 apparently healthy women were enrolled in this study. To investigate immune profile in studied subjects, sera were separated from venous blood sample of each subjects. Enzyme-linked immune-sorbent assay (ELISA) was used to estimate serum levels of GM-CSF, IL-1a, IL-8 , IL-4, IL-10, IL-12 and IL-6. Single radial immunodiffusion (SRID) assay was used to estimate serum levels of C4 and C3. The result of present study showed significant dropping in both of GM-CSF and IL-6 levels, while there wasa significant elevation in IL-8 levels. Each of IL-1a, IL-12, and IL-4 showed non-significant elevation, while IL-10 showed non-significant dropping compared to control group. Levels of C4 showed significant dropping, while C3 levels showed non-significant dropping compared to control group. Conclusions:A significant elevation of proinflammatory cytokines may be due to persistence CMV infection, while non-significant differences in adaptive immunity cytokines may refer to resolution of such immune response following abortion.