Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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In Vitro Bioequivalence for three Products of Warfarin Sodium in Syrian Market

Author(s): Roula Faek Naddour, Nisrin Ali Kaddar

Email(s): roula.naddour@hotmail.com

DOI: 10.5958/0974-360X.2018.00099.9   

Address: Roula Faek Naddour, Nisrin Ali Kaddar Department of Pharmaceutics, Faculty of Pharmacy , Tishreen University, Latakia, Syria *Corresponding Author

Published In:   Volume - 11,      Issue - 2,     Year - 2018

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ABSTRACT:
Three generic warfarin sodium 5mg tablets from different manufacturers had been evaluated to assess their bioequivalence in vitro. Other general quality assessments of these tablets like weight variation, content uniformity, hardness, friability and disintegration time were carried out and all these generic tablets passed these specification tests. To compare the dissolution profiles of all the tablet formulation withthe innovator brand, a model independent approach of difference factor (f1) and similarity factor (f2) was employed with all points included in the in vitro dissolution studies. These results showedthat all generic warfarin sodium tablets included in thisinvestigation were not bioequivalent with the chosen innovator brand, but two generic tablets were bioequivalent between each other.


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Cite this article:
Roula Faek Naddour, Nisrin Ali Kaddar. In Vitro Bioequivalence for three Products of Warfarin Sodium in Syrian Market. Research J. Pharm. and Tech 2018; 11(2):532-536. doi: 10.5958/0974-360X.2018.00099.9


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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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