ABSTRACT:
Objective:The anti-ulcer activity of ethanolic extract of Indigofera tinctoria (Fabaceae) leaf (EEIT) was investigated in Indomethacin and ethanol induced ulcer models in wistar rats. Methods: The preliminary Phytochemical evaluation was carried out by standard methods. Indomethacin and ethanol induced ulcer models the common parameter determined was ulcer index. Animals are divided in to four groups. First groups serves as control, second group treated with standard drug third and fourth group treated with EEIT at doses of 200 and 400 mg/kg p.o produced significant inhibition of the gastric lesions induced by Indomethocin induced ulcer and Ethanol induced gastric ulcer. Results: Phytochemical evaluation shows that alkaloids and flavonoids are present in extract.The extract (200 mg/kg and 400 mg/kg) showed significant (P<0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. This present study indicates that Indigofera tinctoria extract have potential anti ulcer activity in the both models.Cellular level changes was reveled with histopathological studies. Conclusion:These results may further suggest that ethanolic extract was found to possess antiulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity.