Author(s): S. Hemchand, R. Ravi Chandra Babu, Mukthinuthalapati Mathrusri Annapurna

Email(s): hemchand.suryadevara@gmail.com

DOI: 10.5958/0974-360X.2018.01022.3   

Address: S. Hemchand1*, R. Ravi Chandra Babu1, Mukthinuthalapati Mathrusri Annapurna2
1GITAM Institute of Science, GITAM (Deemed to be University), Visakhapatnam, India
2GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam-530045, India
*Corresponding Author

Published In:   Volume - 11,      Issue - 12,     Year - 2018


ABSTRACT:
A new liquid chromatographic method has been developed for the simultaneous determination of Sofosbuvir and Velpatasvir in oral dosage forms. Shimadzu Model CBM-20A/20 Alite with C8 (Phenomenex) column (250 mm × 4.6 mm i.d., 5 µm particle size) was used for the chromatographic study. Linearity was observed over the concentration range 4.54-400.14 µg/ml and 1.09-100.36 µg/ml with regression equations y = 26855x + 83874 (correlation coefficient 0.9997) and y = 35840x + 8543.8 (correlation coefficient 0.9999) for Sofosbuvir and Velpatasvir respectively. Sofosbuvir and Velpatasvir were subjected to forced degradation and the method was validated as per ICH guidelines.


Cite this article:
S. Hemchand, R. Ravi Chandra Babu, Mukthinuthalapati Mathrusri Annapurna. New stability indicating RP-UFLC method for the simultaneous determination of Velpatasvir and Sofosbuvir in tablets. Research J. Pharm. and Tech 2018; 11(12): 5637-5642. doi: 10.5958/0974-360X.2018.01022.3

Cite(Electronic):
S. Hemchand, R. Ravi Chandra Babu, Mukthinuthalapati Mathrusri Annapurna. New stability indicating RP-UFLC method for the simultaneous determination of Velpatasvir and Sofosbuvir in tablets. Research J. Pharm. and Tech 2018; 11(12): 5637-5642. doi: 10.5958/0974-360X.2018.01022.3   Available on: https://rjptonline.org/AbstractView.aspx?PID=2018-11-12-71


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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