Author(s): Manoj Jaybhaye, Pradnya Jagtap, Vaishali Unadle, Sachin Shinde, Gajanan Bhagvat, Ashwin porwal, Vishakha jagtap

Email(s): manojjaybhaye@gmail.com

DOI: 10.5958/0974-360X.2018.00918.6   

Address: Manoj Jaybhaye1, Pradnya Jagtap1, Vaishali Unadle1, Sachin Shinde2, Gajanan Bhagvat3, Ashwin porwal3, Vishakha jagtap1
1Department of Pharmacology, S.G.R.S. College of Pharmacy Saswad, Pune
2Shri. R. D. Bhakt College of Pharmacy, Jalna, Maharashtra, India
3Helling Hand Herbs, Tilak Road, Pune
*Corresponding Author

Published In:   Volume - 11,      Issue - 11,     Year - 2018


ABSTRACT:
In present investigation we evaluated of hypolipidemic potential of a Polyherbal formulation in High cholesterol containing diet induced hyperlipidemia in experimental rats. Hyperlipidemia was induced in 18 rats. HCCD were given orally to induce Hyperlipidemia. HCCD given to all rat except normal group upto 10 days. Hyperlipidemia was confirmed on 10th day by evaluating blood glucose level. Orally administered atervastatin at 1.2 mg/kg/per day served as a standard. Polyherbal formulation (LC-01) was given orally at 500 mg/kg daily to rats for 28 days, and body weight as well as blood glucose, total cholesterol, triglyceride, HDL cholesterol levels were determined at 7 days intervals and compared with those of control and standard groups. LC-01 treated rat’s shows normal gain in body weight as compared to DC group. DC groups showed significantly increased level of blood glucose, total cholesterol, triglycerides and a higher level of HDL cholesterol. The group that received the polyherbal formulation had significantly reduced levels of serum blood glucose, total cholesterol, triglycerides and a higher level of HDL cholesterol. The polyherbal formulation exerts antihyperlipidemic and anti-obesity activities comparable to those of a modern lipid-lowering agent (atorvastatin) in rats.


Cite this article:
Manoj Jaybhaye, Pradnya Jagtap, Vaishali Unadle, Sachin Shinde, Gajanan Bhagvat, Ashwin porwal, Vishakha jagtap. Evaluation of Hypolipidemic Potential of a Polyherbal Formulation in Experimental Rats. Research J. Pharm. and Tech 2018; 11(11): 5037-5041. doi: 10.5958/0974-360X.2018.00918.6


Recomonded Articles:

Author(s): S. Subasree, Karthikeyan Murthykumar, Dhanraj

DOI: 10.5958/0974-360X.2016.00116.5         Access: Open Access Read More

Author(s): S. R Suseem, Dhanish Joseph

DOI: 10.5958/0974-360X.2019.00067.2         Access: Open Access Read More

Author(s): Josephin Nerling Rashida G., T. Venkatarathnakumar, R. Gowri, Ajithadhas Aruna

DOI: Not Available         Access: Open Access Read More

Author(s): Mahanthesh M.C., Girendra Gautam, Jalalpure S.S.

DOI: 10.5958/0974-360X.2017.00250.5         Access: Open Access Read More

Author(s): Anis Fathima. A. G, Vara Prasanna Rao, P. Shanmugasundaram

DOI: 10.5958/0974-360X.2017.00385.7         Access: Open Access Read More

Author(s): Aniruddh Menon, M.S.Thenmozhi

DOI: 10.5958/0974-360X.2016.00307.3         Access: Open Access Read More

Author(s): Kalaivanan S, Sarumathy S, Anisha Ebens J, Naresh Kumar K, Roobena Parveen A, Nasreen Ashraf M.

DOI: 10.5958/0974-360X.2017.00005.1         Access: Open Access Read More

Author(s): Roghith Kannan, Karpagam Krishnamoorthy

DOI: 10.5958/0974-360X.2016.00242.0         Access: Open Access Read More

Author(s): Ranadheer Chowdary P, Praveen. D, Vijey Aanandhi. M

DOI: 10.5958/0974-360X.2017.00086.5         Access: Open Access Read More

Author(s): Fatemeh Haidari, Esmat Mansoori, Mehrnoosh Zakerkish, Mohammadhossein Haghighizadeh

DOI: 10.5958/0974-360X.2017.00263.3         Access: Open Access Read More

Author(s): Thamarai1, Nivetha2, P.M. Durai Raj Vincent3, S.S. Manivannan4;

DOI: 10.5958/0974-360X.2018.00179.8         Access: Open Access Read More

Author(s): A. Rajendra Kumar, N. J. Muthukumar, A. Faridha

DOI: 10.5958/0974-360X.2019.00081.7         Access: Open Access Read More

Author(s): Nor Masitah Mohamed Shukri, Vishnupriya. V. , Gayathri R. , Surapaneni Krishna Mohan

DOI: 10.5958/0974-360X.2016.00334.6         Access: Open Access Read More

Author(s): R. Kumar, M. I. Khan, M. Prasad, Badruddeen

DOI: 10.5958/0974-360X.2019.00432.3         Access: Open Access Read More

Author(s): TMM John Bastin, Panagal Mani, R Arun kumar and Muthuvel Arumugam

DOI: Not Available         Access: Open Access Read More

Author(s): Budhwani Ashok K., Shrivastava B., Singhai A.K., Gupta Prashant

DOI: Not Available         Access: Open Access Read More

Author(s): Bhupen Kalita, Malay K. Das, Anil Kumar Sharma

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags