ABSTRACT:
The purpose of the present study was to formulate and evaluatesustained release tablet of Torsemide. Sustained release tablets of Torsemide were formulated with different concentrations of HPMC K4M and HPMC K100M by using wet granulation technique and evaluated for the different evaluation parameters such as thickness, hardness, drug content uniformity, friability, in-vitro drug releasestudies, release kinetic studies and stability studies were performed. All the evaluation parameters results were significant. In-vitro drug releasestudies were performed and drug release kinetics evaluated using the linear regression method was found to follow Zero order, First order, Matrix and Korsemeyer and Peppas’ equation. The drug release mechanism was found Fickian type in most of theformulations. The prepared formulation shows better and significant results for all the evaluated parameters. The formulation F9 shows maximum percentage of drug release (98.2 %) and prolonged release fortime period of about 12 h, thereby improves the bioavailability and patient compliance.