Author(s): Lakshmi. K, Karishma. S k, N.S.S. Chandra Sekhar. G, Narendra Babu. A, Bhargav Kumar. N

Email(s): lakshmikakunuri95@gmail.com

DOI: 10.5958/0974-360X.2018.00890.9   

Address: Lakshmi. K*, Karishma. S k, N.S.S. Chandra Sekhar. G, Narendra Babu. A, Bhargav Kumar. N.
Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur-522 034, Andhra Pradesh, India
*Corresponding Author

Published In:   Volume - 11,      Issue - 11,     Year - 2018


ABSTRACT:
Objective: The aim of this study was to identify the potential of Terminalia chebula as a protective and therapeutic agent against Alzheimer’s disease. Methods: The learning and memory enhancing activity of Terminalia chebula fruit extracts were investigated in rats by using the ethanol- induced cognitive impairment and diazepam induced amnesia and its effects on learning and memory were examined by using Morris water maze (MWM) test. Results: All the groups showed significantly (P value is<0.01 and <0.05) decrease transfer latency at all periods as compared to ethanol and diazepam inducing group. Therefore Fruit extracts of Terminalia chebula exhibited significant learning and memory activity in Alzheimer’s disease. Conclusion: The present study suggests Terminalia chebula that modulate the oxidative stress and be involved in the protective effect against oxidative damage and neurodegenerative diseases in rat.


Cite this article:
Lakshmi. K, Karishma. S k, N.S.S. Chandra Sekhar. G, Narendra Babu. A, Bhargav Kumar. N. Terminalia chebula Retz improve memory and learning in Alzheimer’s Model: (Experimental Study in Rat). Research J. Pharm. and Tech 2018; 11(11): 4888-4891. doi: 10.5958/0974-360X.2018.00890.9

Cite(Electronic):
Lakshmi. K, Karishma. S k, N.S.S. Chandra Sekhar. G, Narendra Babu. A, Bhargav Kumar. N. Terminalia chebula Retz improve memory and learning in Alzheimer’s Model: (Experimental Study in Rat). Research J. Pharm. and Tech 2018; 11(11): 4888-4891. doi: 10.5958/0974-360X.2018.00890.9   Available on: https://rjptonline.org/AbstractView.aspx?PID=2018-11-11-22


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DOI: 10.5958/0974-360X 

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