ABSTRACT:
Background: Diabetes has been increasing at an alarming rate around the world, and experts have relied on remedies from the utilization of ancient drugs that are essentially derived from plants. Aim: The present study aimed to evaluate the antidiabetic potential of Ammania baccifera Linn leaf extracts on streptozotocin induced diabetic rats. Materials and Methods: Diabetes was induced in male albino wistar rats by single intraperitoneal injection of streptozotocin (STZ) (50 mg/kg b.w.). The diabetic rats were administered orally with Ammania baccifera Linn leaf methanolic extract and isolated fraction (AB) at the dose of 250, 500mg/kg b.w. and 25, 50mg/kg b.w. and glibenclamide (600µg/kg b.w.) as standard by oral route for 45 days. Results: Methanolic extracts of Ammania baccifera Linn leaf, its isolated fraction AB and glibenclamide treated diabetic rats showed moderate reduction in blood glucose and glycosylated hemoglobin levels; in addition, plasma insulin and hemoglobin levels were elevated. Results of AB, Methanolic extract of Ammania baccifera Linn leaf were comparable to the standard drug glibenclamide (600µg/kg b.w). Conclusion: The present findings support the usage of the plant extracts for the treatment of diabetes and isolated fraction AB exhibited anti-hyperglycemic activity when compared with standard hypoglycemic agent.