ABSTRACT:
Selective administration of cancer drugs in a specific manner with respect to the physiological need at the tumor site can increase the efficiency of drugs and reduce side effects. Herein, developed a formulation, comprising of anti-cancer drug Lenalidomide conjugated to chitosan (Chs) coated iron oxide nanoparticles (Fe3O4-Chs) via a pH sensitive imine bond formation which enables active topical drug delivery in response to intra cellular pH change was demonstrated for potential treatment of cancer. The particle size was found to be around 40 (mean± SD (n?=?20)) nm. The structural characterization of the synthesized formulation was done by X-ray diffraction, thermo gravimetric analysis, differential scanning calorimetry, Fourier transform infrared spectroscopy, vibrating sample magnetometer and transmission electron microscopy techniques. Therapeutic efficacy of Fe3O4-Lnd nanoparticles (Nps) was carried out in human breast cancer cells (MCF7) and human ovarian cells (SK-OV-3) by MTT assay which showed improved therapeutic efficacy of Lnd with Fe3O4-Lnd nanoparticles compared to free Lnd