Author(s): Gujju. Hima Bindu, Mukthinuthalapati Mathrusri Annapurna

Email(s): bindureddy.frnd@gmail.com

DOI: 10.5958/0974-360X.2018.00839.9   

Address: Gujju. Hima Bindu*, Mukthinuthalapati Mathrusri Annapurna
Department of Pharmaceutical Analysis and Quality Assurance, GITAM Institute of Pharmacy,
GITAM University, Visakhapatnam-530045, India
*Corresponding Author

Published In:   Volume - 11,      Issue - 10,     Year - 2018


ABSTRACT:
Ibrutinib is used for the treatment of mantle cell lymphoma. Mantle cell lymphoma is a fast growing cancer which begins in the cells of immune system. A new HPLC method has been proposed for the quantification of Ibrutinib. Shimadzu Model HPLC system with Kromosil column (250mm x 4.6 mm, 5m particle size) was used for the study. Mixture of phosphate buffer and acetonitrile (45: 55, v/v) with 1.0 mL/min flow rate are the optimized chromatographic conditions and the system was monitored at 295 nm. Ibrutinib shows linearity 3.5–2100 µg/ml with regression equationy = 15528x + 251.16 (R2 = 0.9999). The LOD and LOQ were found to be 0.6927 µg/ml and 2.1578 µg/ml respectively. Stress studies were performed and the method was validated. Assay of marketed formulations was also conducted the system suitability parameters were within the acceptable limits.


Cite this article:
Gujju. Hima Bindu, Mukthinuthalapati Mathrusri Annapurna. A sensitive stability indicating RP-HPLC method for the determination of Ibrutinib - An anti-cancer drug. Research J. Pharm. and Tech 2018; 11(10): 4587-4591. doi: 10.5958/0974-360X.2018.00839.9


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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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