Author(s): Gujju Hima Bindu, Mukthinuthalapati Mathrusri Annapurna

Email(s): bindureddy.frnd@gmail.com

DOI: 10.5958/0974-360X.2018.00832.6   

Address: Gujju Hima Bindu*, Mukthinuthalapati Mathrusri Annapurna
Department of Pharmaceutical Analysis and Quality Assurance, GITAM Institute of Pharmacy,
GITAM (Deemed to be University, Visakhapatnam-530045, India
*Corresponding Author

Published In:   Volume - 11,      Issue - 10,     Year - 2018


ABSTRACT:
The authors have proposed a new stability indicating RP-HPLC method for the determination of Fingolimod capsules. Symmetry C18 (150 x 4.6 mm, 5µm particle size) column was used for the chromatographic separation with 0.1 % Trifluoro acetic acid: Acetonitrile (50: 50, v/v) mixture as mobile phase. Fingolimod was monitored at 220 nm (UV detector) and the elution was on gradient mode.The flow rate was 1.2 mL/min and the total run time is 10mins. Forced degradation studies were performed to verify the specificity of the method. Beer-Lambert’s law was obeyed over the concentration range 0.5-75 µg/mL with linear regression equation, y = 58537x + 10039 and correlation coefficient 0.9999. The LOD and LOQ are found to be 0.0129 and 0.4061 µg/mL respectively. The proposed method was validated as per ICH guidelines.


Cite this article:
Gujju Hima Bindu, Mukthinuthalapati Mathrusri Annapurna. A New stability indicating liquid chromatographic method for the quantification of Fingolimod – An Immunomodulating drug. Research J. Pharm. and Tech 2018; 11(10): 4547-4552. doi: 10.5958/0974-360X.2018.00832.6

Cite(Electronic):
Gujju Hima Bindu, Mukthinuthalapati Mathrusri Annapurna. A New stability indicating liquid chromatographic method for the quantification of Fingolimod – An Immunomodulating drug. Research J. Pharm. and Tech 2018; 11(10): 4547-4552. doi: 10.5958/0974-360X.2018.00832.6   Available on: https://rjptonline.org/AbstractView.aspx?PID=2018-11-10-62


Recomonded Articles:

Author(s): A. S. K. Sankar, B. Datchayani, N. Balakumaran, Mohammed Rilwan, R. Subaranjani

DOI: 10.5958/0974-360X.2017.00047.6         Access: Open Access Read More

Author(s): Peethala Prathyusha, Raja Sundararajan, Palyam Bhanu, Mathrusri Annapurna Mukthinuthalapati

DOI: 10.5958/0974-360X.2020.00507.7         Access: Open Access Read More

Author(s): Rekha Rajendran, R Hemachander, T Ezhilarasan, C Keerthana, DL Saroja, KV Saichand, Mohamed Gasim Abdullah

DOI: Not Available         Access: Open Access Read More

Author(s): R. P. Bhole, S. R. Jagtap, K. B. Chadar, Y. B. Zambare

DOI: 10.5958/0974-360X.2020.00189.4         Access: Open Access Read More

Author(s): Mayanka Singh, Manoj Charde, Rajesh Shukla, Rita M. Charde

DOI: Not Available         Access: Open Access Read More

Author(s): Vijaykumar T. Pawar, Shubhangi V. Pawar, Harinath N. More, Anita S. Kulkarni, Dinanath T. Gaikwad

DOI: 10.5958/0974-360X.2017.00724.7         Access: Open Access Read More

Author(s): Mukta D. Naykode, Durgacharan A. Bhagwat, Swapnil D. Jadhav, Harinath N. More

DOI: 10.5958/0974-360X.2017.00133.0         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags