Author(s): M. Gnana Raja, G. Geetha

Email(s): Laconil2002@yahoo.com

DOI: 10.5958/0974-360X.2018.00808.9   

Address: M. Gnana Raja1, Dr. G. Geetha2
1KMS Health Center, Chennai, India.
2PSG College of Pharmacy, Coimbatore, India.
*Corresponding Author

Published In:   Volume - 11,      Issue - 10,     Year - 2018


ABSTRACT:
Metals such as Lead, Aluminium and Tin might some suppliers used in the synthesis of collapsible tube or some trace amount might instantly present in the raw materials of collapsible container. A selective ion determination method was developed by ICP OES for leachable and extractable of metal impurities. The method has been validated by using the parameters RF power of 1.2 KV, plasma flow of 15 L/min, Auxiliary gas flow of 1.5 L/min and plasma view at axial mode for all the metals. The wavelength was monitored for Lead, Aluminium and Tin at 220.353nm, 396.152 and 189.925 nm respectively. The method described is simple, sensitive, rugged, reliable and reproducible for the quantization of Lead, Aluminium and Tin in the leachate and extract from the drug product and container respectively.In this paper completely demonstrated the method of quantification of metal impurities Lead, Aluminium and Tin as a leachate and extract by ICP OES for varies solvents, stress condition and different extraction procedure for marketed eye drops availed in southern part of India.


Cite this article:
M. Gnana Raja, G. Geetha. A Concise Study of Metal Impurities as Leachable and Extractable [Lead, Aluminium and Tin] in Eye Drop Formulation and Collapsible Tubes by ICP OES method. Research J. Pharm. and Tech 2018; 11(10): 4415-4420. doi: 10.5958/0974-360X.2018.00808.9

Cite(Electronic):
M. Gnana Raja, G. Geetha. A Concise Study of Metal Impurities as Leachable and Extractable [Lead, Aluminium and Tin] in Eye Drop Formulation and Collapsible Tubes by ICP OES method. Research J. Pharm. and Tech 2018; 11(10): 4415-4420. doi: 10.5958/0974-360X.2018.00808.9   Available on: https://rjptonline.org/AbstractView.aspx?PID=2018-11-10-38


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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