ABSTRACT:
Aim and Background: Oral Squamous cell Carcinoma (OSCC) represents the sixth most common cancer, accounting for 2-4% of all malignancies worldwide. Overall survival rate is less than 60%. OSCC is 2 to 3 times more prevalent in men than women. Important cause for this cancer is toxicity produced by the Reactive Oxygen Species (ROS). Elimination of this ROS helps to prevent the prognosis of the disease. This elimination is done by Antioxidants. There were very few studies on metabolic antioxidant status in OSCC. So, aim of this study was to estimate the level of metabolic antioxidants (Uric acid and Bilirubin) in OSCC patients and assess their role on prevention of the disease. Method and Materials: The study group included 25 OSCC patients and 25 age and sex matched healthy subjects as a control group. Serum uric acid and Bilirubin were analysed byUricase and Diazomethod respectively Using ERBA CHEM 5Plus Analyser. Statistical analysis was performed using Student T Test. P<0.05 was considered to be significant. Result: The mean serum Uric acid level in study and control groups were 3.50±0.93 and 5.8±0.84 respectively. The mean serum Bilirubin level in study and control groups were 0.26±0.16 and 0.57±0.23 respectively. These levels were low in the study group when compared to the control group with the significant p value of 0.0001. Conclusion: In OSCC, due to excessive production of ROS, the uric acid and Bilirubin levels were reduced. So assessment of these levels may helpful to assess the prognosis of the disease and select the proper therapeutic options.