Author(s): Remal Abdulaziz Asaad


DOI: 10.5958/0974-360X.2017.00532.7   

Address: Remal Abdulaziz Asaad
Assistant Professor, Department of Biochemistry and Microbiology, Faculty of Pharmacy, Tishreen University, Lattakia, Syria
*Corresponding Author

Published In:   Volume - 10,      Issue - 9,     Year - 2017

Background: Breast cancer is the most common form of cancer among women worldwide, with the increase incidence and its associated morbidity, mortality, and enormous treatment costs, there is a great interest in strategies of prevention and detection of early prognostic factors. Serum CRP levels could be a marker of increased risk for breast cancer. Aim of the study: Evaluation of estrogen-receptor ER, progesterone-receptor PR and human epidermal growth factor receptor 2 Her-2 expression in 60 female-patients of breast cancer in Jableh-Syria, and studying their relation with serum CRP levels and other prognostic factors. Patients and methods: 60 female- patients of breast cancer aged between 32 to 77 years old, admitted in National hospital of Jableh (Jableh- Syria) were selected from December 2015 until December 2016. Blood samples were collected for CRP levels on admission and measured by immunoturbidimetric determination, levels >5mg/l were considered positive. ER- receptor, PR- receptor and Her-2 expression were assessed. Results: Triple positive receptors TP was the major subgroup of patients (n=21, 35%, p. value= 0.049). Relation between ER-receptor and PR-receptor expression was strongly significant (n= 37, 90.24%, p. value < 0.0001), Patients positive for Her-2 receptor expression were =46 years (n=27, 84.38%, p, value=0.039). Patients positive for serum CRP levels were positive for ER-receptor expression (n=26, 63.41%, p. value=0.021). Mean of CRP levels were increased with stage and difference was not significant. Patients with positive lymph nodes count >4 had higher grade (n=28, 75.78%, p. value= 0.009) and stage (n=24, 64.86%, p. value= 0.002), and were positive for PR-receptor expression (n=31, 83.71%, p. value= 0.008). Conclusion: 90% of patients have same histological diagnosis (invasive ductal carcinoma IDC), but present high variety of ER-receptor, PR-receptor and Her-2 receptor expression as heterogenic subtypes breast cancer, which propose different strategies of prevention and protocols of therapy. CRP levels could be a biomarker for invasive and progression of cancer according to stage and pN staging. Serum CRP levels could predict patients positive for ER-receptor, those who will benefit of modulation of ER-receptor expression as a routine strategy of prevention.

Cite this article:
Remal Abdulaziz Asaad. Hormone Receptor Status and its Relation to C-Reactive Protein and other Prognostic factors in Breast Cancer in Jableh- Syria. Research J. Pharm. and Tech. 2017; 10(9): 3003-3010. doi: 10.5958/0974-360X.2017.00532.7

Recomonded Articles:

Author(s): R. Suresh, D. Benitojohnson, C. Maheswari, R. Venkatnarayanan, R.Manavalan

DOI: 10.5958/0974-360X.2017.00128.7         Access: Open Access Read More

Author(s): Sarika R. Deshmukh, Solomon Habtemariam, Prasad A. Wadegaonkar

DOI:         Access: Open Access Read More

Author(s): RA Hajare, KS Parwani, SA Bajad, NA. Chandekar, AVChandewar

DOI:         Access: Open Access Read More

Author(s): Shukla Maitri Jayeshkumar, Patel Yashvi, Bhavin Bhimani, Ghanshyam Patel, Jaimin Patel, Upendra Patel

DOI: 10.5958/0974-360X.2019.00157.4         Access: Open Access Read More

Author(s): Chiranji Lal Chowdhary, Tapan Kumar Das, Vijaykumar Gurani, Abhishek Ranjan

DOI: 10.5958/0974-360X.2018.00637.6         Access: Open Access Read More

Author(s): Fadilah Fadilah, Lowilius Wiyono, Brenda Cristie Edina, Risya Amelia Rahmawati, Linda Erlina, Aryo Tedjo, Rafika Indah Paramita

DOI: 10.5958/0974-360X.2019.00400.1         Access: Open Access Read More

Author(s): Saadon Abdulla Aowda, Muhammad Hazim, Khalijah Awang, Yumi Zuhanis Has-Yun Hashim, Phirdaous Abbas

DOI: 10.5958/0974-360X.2019.00713.3         Access: Open Access Read More

Author(s): Eva Rachmi, Basuki Bambang Purnomo, Agustina Tri Endharti, Loeki Enggar Fitri

DOI: 10.5958/0974-360X.2020.00171.7         Access: Closed Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles