ABSTRACT:
The intestinal digestive enzymes like alpha-glucosidase and alpha-amylase are played a vital role in the carbohydrate metabolism. Alpha-glucosidase inhibitors are the saccharides that act as competitive inhibitors of enzymes needed for the carbohydrates regulation specifically alpha-glucosidase enzymes in the striated border of the small lintestines. The membrane bound intestinal alpha glucosidases hydrolyze oligosaccharides, trisaccharides and disaccharides to glucose and other monosaccharides in the small intestine. One antidiabetic therapeutic approach to reduce the postprandial glucose level in blood by the inhibition of alpha-glucosidase and alpha-amylase enzymes. These can be an important strategy for the management of blood glucose level in the body. The aim of the present study was to investigate the phytochemical bioactive compounds of the ethanolic extract of Alternanthera ficodia Linn leaves and its Invitro antidiabetic activity. The result suggests that the presence of bioactive compounds could be responsible for the versatile medicinal properties of this plant including diabetes and the extract exhibit the dose-dependent action by increasing the inhibitory effect on alpha-glucosidase enzyme and alpha-amylase enzyme. The ethanolic extract of Alternanthera ficodia Linn leaves study exhibited potent hypoglycemic activity by In vitro studies.