Author(s): Rajesh B. Nawale, Uday A. Deokate, Sadhana R. Shahi, Pradeep M. Lokhande

Email(s): nawale_pharmacy@yahoo.com

DOI: 10.5958/0974-360X.2017.00525.X   

Address: Rajesh B. Nawale1, Uday A. Deokate2, Sadhana R. Shahi2, Pradeep M. Lokhande2
1Govt. College of Pharmacy, Osmanpura, Aurangabad – 431 005 (M.S).
2Govt. College of Pharmacy, Vidyanagar, Karad, Dist Satara – 415 110 (M.S).
*Corresponding Author

Published In:   Volume - 10,      Issue - 9,     Year - 2017


ABSTRACT:
Poorly water-soluble drugs pose many problems in formulation in conventional dosage forms. One of the critical problems associated with those drugs is low bioavailability and erratic absorption. The problem is even more complex for drugs (belonging to BCS CLASS II) as they are poorly soluble in both aqueous and organic media, and for those drugs having a log P value of 2. Nano-suspensions have emerged as a promising strategy for the efficient delivery of hydrophobic drugs because of their versatile features and unique advantages The purpose of this investigation was to reduce the particle size of efavirenz by top down approach i.e. by using high speed homogenizer. The main objective of the study is to prepare nano-suspension of efavirenz by applying design expert and evaluation of nano-suspension.


Cite this article:
Rajesh B. Nawale, Uday A. Deokate, Sadhana R. Shahi, Pradeep M. Lokhande. Formulation and Characterization of Efavirenz Nanosuspension by QbD approach. Research J. Pharm. and Tech 2017; 10(9):2960-2972. doi: 10.5958/0974-360X.2017.00525.X

Cite(Electronic):
Rajesh B. Nawale, Uday A. Deokate, Sadhana R. Shahi, Pradeep M. Lokhande. Formulation and Characterization of Efavirenz Nanosuspension by QbD approach. Research J. Pharm. and Tech 2017; 10(9):2960-2972. doi: 10.5958/0974-360X.2017.00525.X   Available on: https://rjptonline.org/AbstractView.aspx?PID=2017-10-9-25


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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