Author(s): Jeyabaskar Suganya, Viswanathan T, Mahendran Radha, Nishandhini Marimuthu

Email(s): suganyaj11@gmail.com

DOI: 10.5958/0974-360X.2017.00515.7   

Address: Jeyabaskar Suganya1*, Viswanathan T2, Mahendran Radha, Nishandhini Marimuthu1
1Department of Bioinformatics, School of Life Sciences, Vels University, Pallavaram, Chennai-17. TamilNadu, India
2 Department of Microbiology, LRG Govt. Arts College of Women, Tiruppur- 641 604, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 10,      Issue - 9,     Year - 2017


ABSTRACT:
The third leading cause of death in the world is Diabetes. Diabetes comes under a group of metabolic disorders in which the patients possess high blood glucose level. Camptothecin is an alkaloid compound with better antioxidant activity and in china it was used as traditional drugs to cure many diseases. The early researches on camptothecin revealed that it possess better anticancer and antitumor activity when compared with current available synthetic drugs. In silico drug designing and docking studies pave a way for better understanding of inhibitory activity of the compound over the respective target proteins. Molecular docking is one of the most powerful tools for predicting and analyzing the binding interactions between receptors and small molecules at the atomic level. In the current study, an in silico binding interaction of the compound camptothecin with three important diabetic targets like Glucokinase, insulin receptor and PPAR gamma were analyzed using Arguslab. ArgusLab software is used for molecular docking, to study the interactions between small compounds and its proteins. The compound camptothecin was first tested for its drug likeliness, bioactive properties and the results predicted that the compound passed the test for being an oral drug. The docking study revealed that camptothecin showed best binding affinity towards all the three proteins. Among the three proteins, PPAR gamma protein exhibited the lowest binding energy, followed by Glucokinase and insulin receptor with the binding energy of > - 8.5 kcal/mol. Thus, Camptothecin compound could be considered as a better lead molecule in the development and discovery of new anti-diabetic drugs.


Cite this article:
Jeyabaskar Suganya, Viswanathan T, Mahendran Radha, Nishandhini Marimuthu. In silico Molecular Docking studies to investigate interactions of natural Camptothecin molecule with diabetic enzymes. Research J. Pharm. and Tech. 2017; 10(9): 2917-2922. doi: 10.5958/0974-360X.2017.00515.7


Recomonded Articles:

Author(s): P.Maheshwari, D.Pavithra, Neethu.T.T, T.S. Shanmugarajan, P. Shanmugasundaram

DOI: 10.5958/0974-360X.2017.00011.7         Access: Open Access Read More

Author(s): S. Subasree, Karthikeyan Murthykumar, Dhanraj

DOI: 10.5958/0974-360X.2016.00116.5         Access: Open Access Read More

Author(s): Santhosh Kumar V, Praveen D

DOI: 10.5958/0974-360X.2016.00123.2         Access: Open Access Read More

Author(s): Leelavathi D Acharya, N R Rau, N Udupa, Surulivel Rajan M, Vijayanarayana K

DOI: 10.5958/0974-360X.2016.00162.1         Access: Open Access Read More

Author(s): T. Arunkumar, Ann Feba Ebby, G. Narendrakumar

DOI: 10.5958/0974-360X.2017.00441.3         Access: Open Access Read More

Author(s): S.M. Charjan, S.K. Bais, R.R. Shiradkar, R.L. Bakal, V.M. Durge, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): Vaddi Mounika, S. Sarumathy, J. Anisha Ebens, T. S. Shanmugarajan

DOI: 10.5958/0974-360X.2017.00003.8         Access: Open Access Read More

Author(s): Surendra Nath Pandeya, Rajeev Kumar, Arun Kumar, Ashish Kumar Pathak

DOI: Not Available         Access: Open Access Read More

Author(s): Shikha Batra, Nikhil Batra, Anil Pareek, Badri Prakash Nagori

DOI: Not Available         Access: Open Access Read More

Author(s): Kalaivanan S, Sarumathy S, Anisha Ebens J, Naresh Kumar K, Roobena Parveen A, Nasreen Ashraf M.

DOI: 10.5958/0974-360X.2017.00005.1         Access: Open Access Read More

Author(s): Ranadheer Chowdary P, Praveen. D, Vijey Aanandhi. M

DOI: 10.5958/0974-360X.2017.00086.5         Access: Open Access Read More

Author(s): Fatemeh Haidari, Esmat Mansoori, Mehrnoosh Zakerkish, Mohammadhossein Haghighizadeh

DOI: 10.5958/0974-360X.2017.00263.3         Access: Open Access Read More

Author(s): Deepak H B, Sabina Evan Prince

DOI: 10.5958/0974-360X.2017.00491.7         Access: Open Access Read More

Author(s): Roghith Kannan, Karpagam Krishnamoorthy

DOI: 10.5958/0974-360X.2016.00242.0         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags