Author(s): Ayyakannu Arumugam Napoleon, Vijay Sharma

Email(s): aanapoleon@vit.ac.in , napoleonaa@gmail.com

DOI: 10.5958/0974-360X.2017.00432.2   

Address: Ayyakannu Arumugam Napoleon*, Vijay Sharma
Pharmaceutical Chemistry Laboratory, SAS, VIT University, Vellore - 632014, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 10,      Issue - 8,     Year - 2017


ABSTRACT:
In the present work, the three synthesized isochromen-1-one, their thio and N-methylated analogues derived from the anti-inflammatory drug Etodolac are assessed for its in-vitro anti-inflammatory activity and carried out molecular docking studies. Docking study result shows that compound,5 possess good binding affinity with the COX-1 receptor showing a docking score of -8.2 and lipophilic interaction of -2.5 which is greater when compared to standard drugs such as Etodolac, Aceclofenac and Diclofenac were used. The same compound 5 also shows comparable in-vitro anti-inflammatory activity with etodolac as standard in both the methods screened.


Cite this article:
Ayyakannu Arumugam Napoleon, Vijay Sharma. Molecular Docking and In-vitro anti-inflammatory evaluation of Novel Isochromen-1-one analogues from Etodolac. Research J. Pharm. and Tech. 2017; 10(8): 2446-2450. doi: 10.5958/0974-360X.2017.00432.2


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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