Author(s): T. Arunkumar, Ann Feba Ebby, G. Narendrakumar

Email(s): ap_arunkumar@yahoo.com

DOI: 10.5958/0974-360X.2017.00441.3   

Address: T. Arunkumar1*, Ann Feba Ebby1, G. Narendrakumar2 1Department of Bioinformatics, School of Bio and Chemical Engineering, Sathyabama University, Chennai 600119. 2Department of Biotechnology, School of Bio and Chemical Engineering, Sathyabama University, Chennai 600119. *Corresponding Author

Published In:   Volume - 10,      Issue - 8,     Year - 2017


ABSTRACT:
Objectives: The White Spot Syndrome Virus (WSSV) is the contagious and lethal disease that causes high mortality rates in shrimps. Effective tools and techniques exist to determine how serious of a problem it can be and to moderate its impact at this time. Method: The Crystal Structure of Envelope Protein VP28 from WSSV was downloaded from the protein data bank (PDB) a database for the three-dimensional of proteins with PDB ID 2ED6 with the sequence length of 2040 amino acid residues. The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug. The ligand for target protein zonisamide (1,2-benzoxazol-3-ylmethanesulfonamide) is a compound downloaded from the DrugBank database. binding site of the receptor molecule is predicted using Discovery studio, a software suite for simulating small and macromolecular systems developed by Accelrys. Results: Based on the target structure Crystal Structure of Envelope Protein VP28 and the ligand compound zonisamide the 64-binding site was identified using discovery studio and in that 10th site was reported as an active binding site which is having high scoring function. Active site is done for all the analogues in the 10th site. 293 analogs 72 ligand ADMT satisfy- pharmophore using hiphop hypothesis 10 using rank. Ligand fit identification docking 159 poses were obtained- rank 5 used as results – PLP value Jain score PMF Dock score rotation bond of the ligand internal energy.


Cite this article:
T. Arunkumar, Ann Feba Ebby, G. Narendrakumar. Docking studies of Benzisoxazole analogues in White Spot Syndrome Virus. Research J. Pharm. and Tech. 2017; 10(8): 2497-2500. doi: 10.5958/0974-360X.2017.00441.3


Recomonded Articles:

Author(s): Abhirup Dey, Mangala Lakshmi Ragavan, Sanjeeb Kumar Mandal, Nilanjana Das

DOI: 10.5958/0974-360X.2017.00136.6         Access: Open Access Read More

Author(s): Vandana Gautam, Dhriti Kapoor, Saroj Arora, Renu Bhardwaj*

DOI: 10.5958/0974-360X.2016.00166.9         Access: Open Access Read More

Author(s): A. Julius, Ramachandran Vedasendiyar, Archana Devakannan, Sujatha Rajaraman, Balamurugan Rangasamy, V. Saravanan

DOI: 10.5958/0974-360X.2017.00062.2         Access: Open Access Read More

Author(s): Dhanalekshmi UnniKrishnan Nair, MP Saraswathy, Narra Kishore, Neelakanta Reddy Pully

DOI: Not Available         Access: Open Access Read More

Author(s): T. Arunkumar, Ann Feba Ebby, G. Narendrakumar

DOI: 10.5958/0974-360X.2017.00441.3         Access: Open Access Read More

Author(s): Homendra Kumar Sahu, Kamdev Sen, Raju Patel, Hulash Sahu, Deepika Sahu, Gulshan Sahu, Chandrashekhar Jain, Narayan Prasad Chandra, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00173.1         Access: Open Access Read More

Author(s): Krishnendu Acharya*, Somanjana Khatua, Salman Sahid

DOI: Not Available         Access: Open Access Read More

Author(s): Md Kamal Hossain, Kamrun Nahar, Parisa Shokryazdan, Norhani Abdullah, Kaiser Hamid, Mohammed Faseleh Jahromi

DOI: 10.5958/0974-360X.2017.00530.3         Access: Open Access Read More

Author(s): Aravind R., Bindu A.R., Bindu K., Alexeyena V.

DOI: Not Available         Access: Open Access Read More

Author(s): Manisha N. Trivedi, Archana Khemani, Urmila D. Vachhani, Charmi P. Shah, D.D. Santani

DOI: Not Available         Access: Open Access Read More

Author(s): Shrivastava Alankar, Jain R., Agrawal R.K., Ahirwar D.

DOI:         Access: Open Access Read More

Author(s): S Hemalatha and M Jegadeesan

DOI: Not Available         Access: Closed Access Read More

Author(s): Mithilesh Kumar, Anshu Deogam, Mradul Tiwari, Venkatesh Kamath

DOI: 10.5958/0974-360X.2017.00305.5         Access: Open Access Read More

Author(s): Vijay Simha G.1, Meena Ajay Kumar1, Sannd Rajesh1, Panda P.2 and M.M. Rao3

DOI: Not Available         Access: Open Access Read More

Author(s): Preethi Krishnan, Muralidharan

DOI: 10.5958/0974-360X.2016.00376.0         Access: Open Access Read More

Author(s): R. Pandian , Lalitha Kumari

DOI: 10.5958/0974-360X.2016.00471.6         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags