Author(s): S.B. Prabha, Mohini Rao, M. R. Ramesh Kumar

Email(s): pkprabha27@gmail.com

DOI: 10.5958/0974-360X.2017.00440.1   

Address: S.B. Prabha*, Mohini Rao, M. R. Ramesh Kumar
Department of Microbiology, School of Life Sciences, VELS University, Chennai, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 10,      Issue - 8,     Year - 2017


ABSTRACT:
The present study was aimed to analyze the phytochemicals of leaf extracts of Cleome rutidosperma and to check their antioxidant, antimicrobial and anticancer activities using in vitro methods. The hexane, ethyl acetate and methanol extracts of C. rutidosperma were extracted using 70%v/v of above mentioned solvents using Rotary evaporator. The phyto-constituents such as alkaloids, flavonoids, tannins, saponins, steroids, proteins and polyphenols were detected using standard chemical methods. The ability of plant extracts to scavenge the stable free radical DPPH was analyzed. The IC50 values of each extracts were determined using the standard graphs. Antibacterial activity of the prepared extracts was performed against Bacillus cereus, Staphylococcus aureus, Escherichia coli and Salmonella typhi. In vitro cytotoxicity of methanol extract of C. rutidosperma was determined using MTT (3-(4,5-Dimethylthiazol-2-Yl)-2, 5-Diphenyltetrazolium Bromide) assay. Among the hexane, ethyl acetate and methanol extracts of leaves of C. rutidosperma, the methanol extract showed positive for all phytochemicals tested in this study except saponins. At a concentration of 150µg/ml the methanol extract showed the zone of inhibition of 12mm against both B. cereus and E. coli, ethyl acetate showed 10mm against S. aureus and 12mm against S. typhi. The methanol extract also exhibited significant antioxidant and anticancer activities. This study reveals that the plant Cleome rutidosperma possesses medicinal properties like antibacterial, antioxidant and anticancer activities.


Cite this article:
S.B. Prabha, Mohini Rao, M. R. Ramesh Kumar. Evaluation of in vitro Antioxidant, Antibacterial and Anticancer activities of leaf extracts of Cleome rutidosperma. Research J. Pharm. and Tech. 2017; 10(8): 2492-2496. doi: 10.5958/0974-360X.2017.00440.1

Cite(Electronic):
S.B. Prabha, Mohini Rao, M. R. Ramesh Kumar. Evaluation of in vitro Antioxidant, Antibacterial and Anticancer activities of leaf extracts of Cleome rutidosperma. Research J. Pharm. and Tech. 2017; 10(8): 2492-2496. doi: 10.5958/0974-360X.2017.00440.1   Available on: https://rjptonline.org/AbstractView.aspx?PID=2017-10-8-10


Recomonded Articles:

Author(s): Niha Naveed, Karthikeyan Murthykumar, Subasree Soundarajan, Sripradha Srinivasan

DOI: Not Available         Access: Open Access Read More

Author(s): Rakhi Mehra, Renu Makhija, Neera Vyas

DOI: Not Available         Access: Open Access Read More

Author(s): Rekha Rajendran, R Hemachander, T Ezhilarasan, C Keerthana, DL Saroja, KV Saichand, Mohamed Gasim Abdullah

DOI: Not Available         Access: Open Access Read More

Author(s): Hayat M. Mukhtar, Vandna Kalsi

DOI: 10.5958/0974-360X.2018.00395.5         Access: Open Access Read More

Author(s): Sandeep D. S, Prashant Nayak, Jobin Jose, Rishal Relita M, Sumana D. R.

DOI: 10.5958/0974-360X.2017.00317.1         Access: Open Access Read More

Author(s): Ranjitha Dhevi V. Sundar, Sugashini Settu, Saranya Shankar, Gayathri Segaran, Mythili Sathiavelu

DOI: 10.5958/0974-360X.2018.00153.1         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Sandeep DS, Narayana Charyulu R, Prashant Nayak, Aliss Maharjan, Indira Ghalan

DOI: 10.5958/0974-360X.2016.00163.3         Access: Open Access Read More

Author(s): Rupali Deshmukh, Roshni Agrawal, Sarita Chauragde, Swati Lilhare, M. U. Mishra

DOI: 10.5958/0974-360X.2018.00831.4         Access: Open Access Read More

Author(s): Trilokchandran. B, Vijayakumar G, Thippareddy K S

DOI: 10.5958/0974-360X.2019.00612.7         Access: Open Access Read More

Author(s): Gopinath G, Thirumal M, P. R. Kumar

DOI: 10.5958/0974-360X.2020.00362.5         Access: Open Access Read More

Author(s): Karpagam T, Jannathul Firdous, Revathy, Shanmuga Priya, Varalakshmi B, Gomathi S, Geetha S, Noorzaid Muhamad

DOI: 10.5958/0974-360X.2019.00360.3         Access: Open Access Read More

Author(s): Dhanalekshmi UnniKrishnan Nair, MP Saraswathy, Narra Kishore, Neelakanta Reddy Pully

DOI: Not Available         Access: Open Access Read More

Author(s): Praveen D, Ranadheer Chowdary P, Gandikota Thanmayi, Gangabathina Poojitha, Vijey Aanandhi M

DOI: 0.5958/0974-360X.2016.00047.0         Access: Open Access Read More

Author(s): Vandana Gautam, Dhriti Kapoor, Saroj Arora, Renu Bhardwaj*

DOI: 10.5958/0974-360X.2016.00166.9         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags