Author(s): Umesh Kumar, Rakesh Narang, Surendra Kumar Nayak, Sachin Kumar Singh, Vivek Gupta

Email(s): rakesh.15772@lpu.co.in , rakesh_nrng@yahoo.co.in

DOI: 10.5958/0974-360X.2017.00425.5   

Address: Umesh Kumar, Rakesh Narang*, Surendra Kumar Nayak, Sachin Kumar Singh and Vivek Gupta
Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara-144401, India
*Corresponding Author

Published In:   Volume - 10,      Issue - 7,     Year - 2017


ABSTRACT:
Benzimidazole is nitrogen containing heterocyclic organic compound. It is a bicyclic compound with fused benzene and imidazole nucleus. Various research groups revealed that benzimidazole is an important lead molecule for the development of anthelmintic, antibacterial, antifungal, antiprotozoal, antimycobacterial and antiviral agents. So, in present review, various biologically important derivatives of benzimidazole have been compiled. On the basis of their biological activity data and substitution pattern around the benzimidazole nucleus, structure activity relationship (SAR) has been analysed. An outline of mechanism of action of benzimidazole derivatives against various biological targets is also presented. Hence, present review can help the researchers in development of new benzimidazole derivative with significant biological activity.


Cite this article:
Umesh Kumar, Rakesh Narang, Surendra Kumar Nayak, Sachin Kumar Singh, Vivek Gupta. Benzimidazole: Structure Activity Relationship and Mechanism of Action as Antimicrobial Agent. Research J. Pharm. and Tech. 2017; 10(7): 2400-2414. doi: 10.5958/0974-360X.2017.00425.5


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