Author(s): Jeong-Sook Park, Jae-Hyeok Lee

Email(s): ,

DOI: 10.5958/0974-360X.2017.00422.X   

Address: Jeong-Sook Park1, Jae-Hyeok Lee*2
1Dept. of Nursing, Nambu University, 23 Chumdan, Jungang-ro, Gwangsan-gu,Gwangju, 506-706, Republic of Korea
2Department of Oriental Pharmaceutical Development, Nambu University,23 Chumdan, Jungang-ro, Gwangsan-gu, Gwangju, 506-706, Republic of Korea
*Corresponding author

Published In:   Volume - 10,      Issue - 7,     Year - 2017

Background/Objectives: The present paper investigated anti Candida effect using four types of fractions extracted from Rhizoma Coptidis. Methods/Statistical analysis: Disk diffusion tests were conducted to see the anti-Candida effect, and 70% ethanol and fluconazole (50mg/ml) were used as positive control group. This was to examine sensitivity on the sample by measuring a diameter of the inhibition zone cultured and created after placing a sample-treated disk. Findings: The test result of Hexane, Chloroform, n-butanol (n-BuOH), and ethyl acetate (EtOAc) showed that a diameter of n-BuOH was 32mm, which was 110% higher inhibition control than that of Fluconazole (50mg/ml) 29mm, which was a positive control group. Since existing antifungal agents have many side-effects, a dosage of existing drugs can be reduced through combined modality therapy using n-BuOH fraction or similar natural substances while similar or improved effect can be obtained. As discussed in the study result in this paper, the discovery of medicinal ingredient with antifungal effects as combined modality therapy can be regarded highly important. Improvements/Applications: In summary, the present study searched antifungal agents of new substance and identified the antifungal effect of n-BuOH fraction extracted from Rhizoma Coptidis on C. albicans infection.

Cite this article:
Jeong-Sook Park, Jae-Hyeok Lee. Mechanism in Antibacterial Activity on Fraction of Coptidis Rhizoma against Candida Albicans. Research J. Pharm. and Tech. 2017; 10(7):2387-2390. doi: 10.5958/0974-360X.2017.00422.X

Recomonded Articles:

Author(s): Kumkum Sarangdevot, Bhawani Singh Sonigara, Amul Mishra, K. C. Gupta, Surbhi Sharma

DOI: Not Available         Access: Open Access Read More

Author(s): Young Mi Ryu, Myungsun Yi

DOI: 10.5958/0974-360X.2017.00421.8         Access: Open Access Read More

Author(s): Adithya Chandrashekar, Anuraag Muralidharan, Ananthamurthy Koteshwara, Angel Treasa Alex, V. M. Subrahmanyam

DOI: 10.5958/0974-360X.2019.00791.1         Access: Open Access Read More

Author(s): A. Khuntia, S.K. Mohanty

DOI: Not Available         Access: Open Access Read More

Author(s): Ji-Hye Park, Seul-Gi Jung, Dong-Yeop Lee, Ji-Heon Hong, Jin-Seop Kim, Jae-Ho Yu

DOI: 10.5958/0974-360X.2017.00404.8         Access: Open Access Read More

Author(s): Jung-Hui Son, Do-Seon Lim, Chang-Hee Kim

DOI: 10.5958/0974-360X.2017.00414.0         Access: Open Access Read More

Author(s): Young-Hoon Lee, Su-Chul Han, Hong-Ryang Jung, Cheong-Hwan Lim

DOI: 10.5958/0974-360X.2017.00484.X         Access: Open Access Read More

Author(s): Jong-Im Kim, Sun Kyung Kim, Hyunjoo Kim, Sunae Kim, Taehui Kim, Keumok Park, Bohyun Kim

DOI: 10.5958/0974-360X.2017.00544.3         Access: Open Access Read More

Author(s): Sun Ae Kim, Sun Kyung Kim, Jong-Im Kim, Ock Ja Chang, Ji Yeon Choi, Mi Ra Nam

DOI: 10.5958/0974-360X.2017.00401.2         Access: Open Access Read More

Author(s): S. Krishnakumar, R. Divya, N.R. Kanchana Devi, G. Keerthana, A. Ancy Judi

DOI: 10.5958/0974-360X.2017.00234.7         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles