Author(s):
Surendra Kumar Nayak, Gopal Lal Khatik, Rakesh Narang, Vikramdeep Monga
Email(s):
surendra_niper@yahoo.com
DOI:
10.5958/0974-360X.2017.00396.1 
Address:
Surendra Kumar Nayak1*, Gopal Lal Khatik1, Rakesh Narang1, Vikramdeep Monga2
1Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi, G.T. Road (NH-1), Phagwara, Punjab-144411
2Department of Pharmaceutical Chemistry, Rajendra Institute of Technology and Sciences, Sirsa, Haryana-125055
*Corresponding Author
Published In:
Volume - 10,
Issue - 7,
Year - 2017
ABSTRACT:
Mdm2 is a well known oncogene which affects expression of various genetic factors. It encoded oncoprotein Mdm2 of 491 amino acids divided into four major domains (p53-binding, acidic, Zn-finger and ring finger). Acting as an E3-ubiquitin ligase, Mdm2 induced degradation of various proteins which affect the cellular transformation such as p53, p73, JMY, FOXO3a, HPIP, HDAC, p21Waf1/CIP1 etc. Thus, Mdm2 found to be responsible for up and down regulation proteins in cellular system and plays crucial role in several human cancers through variety of biological pathways. Here, we described the major classes of human cancers in which Mdm2 involved directly or indirectly. Moreover, mechanistic role of Mdm2 summarised along with intermediates of cellular biochemical pathways regulated or expressed by it.
Cite this article:
Surendra Kumar Nayak, Gopal Lal Khatik, Rakesh Narang, Vikramdeep Monga. Role of Mdm2 Cascade in Human Cancers. Research J. Pharm. and Tech. 2017; 10(7): 2236-2242. doi: 10.5958/0974-360X.2017.00396.1
Cite(Electronic):
Surendra Kumar Nayak, Gopal Lal Khatik, Rakesh Narang, Vikramdeep Monga. Role of Mdm2 Cascade in Human Cancers. Research J. Pharm. and Tech. 2017; 10(7): 2236-2242. doi: 10.5958/0974-360X.2017.00396.1 Available on: https://rjptonline.org/AbstractView.aspx?PID=2017-10-7-47