Author(s): Surendra Kumar Nayak, Gopal Lal Khatik, Rakesh Narang, Vikramdeep Monga

Email(s): surendra_niper@yahoo.com

DOI: 10.5958/0974-360X.2017.00396.1   

Address: Surendra Kumar Nayak1*, Gopal Lal Khatik1, Rakesh Narang1, Vikramdeep Monga2
1Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi, G.T. Road (NH-1), Phagwara, Punjab-144411
2Department of Pharmaceutical Chemistry, Rajendra Institute of Technology and Sciences, Sirsa, Haryana-125055
*Corresponding Author

Published In:   Volume - 10,      Issue - 7,     Year - 2017


ABSTRACT:
Mdm2 is a well known oncogene which affects expression of various genetic factors. It encoded oncoprotein Mdm2 of 491 amino acids divided into four major domains (p53-binding, acidic, Zn-finger and ring finger). Acting as an E3-ubiquitin ligase, Mdm2 induced degradation of various proteins which affect the cellular transformation such as p53, p73, JMY, FOXO3a, HPIP, HDAC, p21Waf1/CIP1 etc. Thus, Mdm2 found to be responsible for up and down regulation proteins in cellular system and plays crucial role in several human cancers through variety of biological pathways. Here, we described the major classes of human cancers in which Mdm2 involved directly or indirectly. Moreover, mechanistic role of Mdm2 summarised along with intermediates of cellular biochemical pathways regulated or expressed by it.


Cite this article:
Surendra Kumar Nayak, Gopal Lal Khatik, Rakesh Narang, Vikramdeep Monga. Role of Mdm2 Cascade in Human Cancers. Research J. Pharm. and Tech. 2017; 10(7): 2236-2242. doi: 10.5958/0974-360X.2017.00396.1


Recomonded Articles:

Author(s): S. Subasree, Karthikeyan Murthykumar, Dhanraj

DOI: 10.5958/0974-360X.2016.00116.5         Access: Open Access Read More

Author(s): V. Padmaharish

DOI: 10.5958/0974-360X.2016.00190.6         Access: Closed Access Read More

Author(s): A. Julius, Ramachandran Vedasendiyar, Archana Devakannan, Sujatha Rajaraman, Balamurugan Rangasamy, V. Saravanan

DOI: 10.5958/0974-360X.2017.00062.2         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): M. A. Fazeelath Banu, Karthikeyan Murthykumar, Dr. Dhanraj

DOI: 10.5958/0974-360X.2016.00184.0         Access: Open Access Read More

Author(s): R. Suresh, D. Benitojohnson, C. Maheswari, R. Venkatnarayanan, R.Manavalan

DOI: 10.5958/0974-360X.2017.00128.7         Access: Open Access Read More

Author(s): Kuldeep Kumar, Neelam Verma

DOI: Not Available         Access: Open Access Read More

Author(s): Arvindganth. R, Anupriya K.V., Kathiravan. G

DOI: 10.5958/0974-360X.2017.00105.6         Access: Open Access Read More

Author(s): V. F. Larichev, I. P. Smirnova, S. P. Syatkin, G. I. Myandina, S. M. Chibisov, Е. А. Ryskina

DOI: 10.5958/0974-360X.2017.00143.3         Access: Open Access Read More

Author(s): Hitesh Jain, Rushi Panchal, Dilrose Pabla, Jaimini Patel, Mansi Khirwadkar

DOI: Not Available         Access: Open Access Read More

Author(s): Rajendra Jangde, S. J. Daharwal

DOI: Not Available         Access: Open Access Read More

Author(s): Sandra Sajen, Jephin Varughese Jose, Sandeep Bukke, Chaithanya Sudha M, Saladi S.V. Subbarao, V.R. Mandla

DOI: 10.5958/0974-360X.2017.00286.4         Access: Open Access Read More

Author(s): Sangeeta S. Tanavade, Smt. Nilofer Naikwade, Dhanyakumar D. Chougule

DOI: Not Available         Access: Open Access Read More

Author(s): Poonam Karekar, Nitin Salunkhe, Adhikrao Yadav, Dnyaneshwar Bangar, Dhanashri Yadav

DOI: Not Available         Access: Open Access Read More

Author(s): Muddukrishna B.S. Krishnamurthy Bhat, Gautham G. Shenoy

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags