Author(s): Rajeev K. Singh, Pushpendra Sharma

Email(s): rajeevbiochem@gmail.com

DOI: 10.5958/0974-360X.2017.00391.2   

Address: Rajeev K. Singh1*, Pushpendra Sharma2
1Research Scholar, Department of Chemistry, Sri Satya Sai University of Technology and Medical Sciences, Opp. Oil-fed Plant, Bhopal-Indore Road, Sehore, Madhya Pradesh-466001, India.
2Sri Satya Sai University of Technology and Medical Sciences, Opp. Oil-fed Plant, Bhopal-Indore Road, Sehore, Madhya Pradesh-466001, India.
*Corresponding Author

Published In:   Volume - 10,      Issue - 7,     Year - 2017


ABSTRACT:
A simple, rapid and precise reversed-phase high performance liquid chromatography method for simultaneous estimation of rosiglitazone maleate, glimepride and amlodipine besylate in a marketed tablet dosage form has been developed and validated. At optimum condition was performed on a C18 column by ratio of mobile phase Methanol: Water: Ortho Phosphoric Acid (75:25:0.2) with maintain of pH 4.5±0.01 at 1.0 mL/min. Selected wavelength at 230 nm and sample volume injected 20 µL at ambient temperature. Total run time was 10 min; rosiglitazone maleate, glimepride and amlodipine besylate were eluted with retention time of 1.75, 2.22 and 6.483 respectively. The developed method was validated as per ICH guideline. Validation revealed that method is specific, rapid, accurate, precise, reliable and reproducible.


Cite this article:
Rajeev K. Singh, Pushpendra Sharma. Simultaneous estimation of Rosiglitazone Maleate, Glimepride and Amlodipine Besylate in Tablet Dosage formulation by RP-HPLC. Research J. Pharm. and Tech. 2017; 10(7): 2213-2220. doi: 10.5958/0974-360X.2017.00391.2


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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