Author(s): S. Madhavi Latha, J. Ramesh Babu

Email(s): madhavilatha61@gmail.com

DOI: 10.5958/0974-360X.2017.00387.0   

Address: S. Madhavi Latha1*, J. Ramesh Babu2
1Department of Pharmaceutics, Aditya Pharmacy College, Aditya Nagar, ADB Road, Surampalem-533437, East Godavari District.
2Department of Pharmaceutics, CHIPS, Chowdavaram, Guntur.
*Corresponding Author

Published In:   Volume - 10,      Issue - 7,     Year - 2017


ABSTRACT:
Methocarbamol, a BCS class II drug is an antispasmodic agent used to treat the spasms from peripheral musculoskeletal conditions. The research focus in recent years has shifted to the formulation of both fast dissolving and disintegrating tablets that are swallowed and tablets that are intended to dissolving in the oral cavity. Super-disintegrants are now frequently used in tablet formulation to improve the rate and extent of tablet disintegration and thus improve the rate of drug dissolution. The majority of this research has been directed at the function-related properties of the super-disintegrants with special emphasis on correlating these properties to disintegrant efficiency and drug release. The present study was to formulate immediate release tablets using various types of disintegrants in order to investigate the effect of mode of incorporation of disintegrants on release of drug from tablets. Methocarbamol immediate release tablets were prepared by the roller compaction method by using a plasdone S630 as binder and four different disintegrants in combination of three modes of incorporation. The prepared tablets were characterized based upon their physicochemical characteristics. The results showed that F4 (CCS) and F7 (PP-XL) 3 % formulations exhibit faster release when compared to others. It may be concluded that intra-granular addition has given improved drug release from dosage form when compared to extra-granular and both intra and extra-granular addition.


Cite this article:
S. Madhavi Latha, J. Ramesh Babu. Comparative study of mode of addition of super Disintegrants on Methocarbamol tablets by Roller Compaction method. Research J. Pharm. and Tech. 2017; 10(7): 2194-2202. doi: 10.5958/0974-360X.2017.00387.0

Cite(Electronic):
S. Madhavi Latha, J. Ramesh Babu. Comparative study of mode of addition of super Disintegrants on Methocarbamol tablets by Roller Compaction method. Research J. Pharm. and Tech. 2017; 10(7): 2194-2202. doi: 10.5958/0974-360X.2017.00387.0   Available on: https://rjptonline.org/AbstractView.aspx?PID=2017-10-7-38


Recomonded Articles:

Author(s): Ahmed Hilal Sheriff, Preetham Prasad Nittla

DOI: 10.5958/0974-360X.2019.00968.5         Access: Open Access Read More

Author(s): Justin Antony, Satadal Debroy, Chennu Manisha, Peet Thomas, Victoria Jeyarani, Tenzin Choephel

DOI: 10.5958/0974-360X.2019.00367.6         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Avinash Bhagwat, Suhas M Kakade, Chirag V Naval, Mukesh Tilker, Ravindra M Walture, Sagar A Adichwal and Atul P Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Pande S. D., Wagh A.S., Bhagure L.B., Patil S.G., Deshmukh A.R.

DOI: 10.5958/0974-360X.2015.00070.0         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Sandesh More, Javed Mirza, Nanasaheb Kale, Mayur Gandhi, Rakesh Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6         Access: Open Access Read More

Author(s): Suchithra. A. B, S. Jeganath, E. Jeevitha

DOI: 10.5958/0974-360X.2019.01073.4         Access: Open Access Read More

Author(s): Poonam Karekar, Nitin Salunkhe, Adhikrao Yadav, Dnyaneshwar Bangar, Dhanashri Yadav

DOI: Not Available         Access: Open Access Read More

Author(s): Mouli Chandar. M Anton Smith. A

DOI: 10.5958/0974-360X.2019.00884.9         Access: Open Access Read More

Author(s): Amutha K*, Ashok Kumar A, Godavari A

DOI: 10.5958/0974-360X.2017.00100.7         Access: Open Access Read More

Author(s): Senthilkumar S., Ajithkumar, Sangeetha. S

DOI: 10.5958/0974-360X.2019.00837.0         Access: Open Access Read More

Author(s): Barokar A.A., Wagh R.D., Baviskar D.T., Shaikh T.J.

DOI: Not Available         Access: Open Access Read More

Author(s): Deependra Jain, Nishiprakash Jain, SK Jain, Nitin Jonwal, Shashank Mishra, Deepak Bhatt, Soham Shukla

DOI: Not Available         Access: Open Access Read More

Author(s): Yarnykh T.G., Azarenko Iu. M., Buryak M.V., Bubilieva L. A.

DOI: 10.5958/0974-360X.2016.00115.3         Access: Open Access Read More

Author(s): Manisha N. Trivedi, Archana Khemani, Urmila D. Vachhani, Charmi P. Shah, D.D. Santani

DOI: Not Available         Access: Open Access Read More

Author(s): Mohammed Ehtesham Ur Rahman, Mohammed Abdul Haseeb, Mohammed Saleem, Abdul Naveed

DOI: Not Available         Access: Open Access Read More

Author(s): Samip Shah, T. Y. Pasha, Dipti Desai, Anil Bhandari

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags