Author(s): Prashant N. Jorapur, Vinod M. Reddy, Vitthal K. Vijapure, Siddu Biradar, Vijaykumar A, Santosh Girani

Email(s): pnjorapur@gmail.com

DOI: 10.5958/0974-360X.2017.00294.3   

Address: Prashant N. Jorapur*, Vinod M. Reddy, Vitthal K. Vijapure, Siddu Biradar, Vijaykumar A, Santosh Girani
B.L.D.E.A’s SSM College of Pharmacy Vijayapura B.LD.E University Campus-586101
S.J.M. College of Pharmacy SJM Campus Chitradurga-577502
*Corresponding Author

Published In:   Volume - 10,      Issue - 6,     Year - 2017


ABSTRACT:
The aim of this work was to prepare and evaluate the gastroretentive mucoadhesive microspheres of Cefpodoxime proxetil. The microspheres were prepared by solvent evaporation method using polymers such as EudragitRS100 and PMMA. The prepared microspheres were characterized for surface morphology, particle size analysis, DSC, FTIR swelling index, DEE and in-vitro drug release study. The prepared microspheres are smooth in surface and spherical in shape. The average particle size was in the range of 120-210 µm. The particle size and shape found to be dependent on the concentration of polymers. Drug entrapment efficiency of Cefpodoxime proxetil loaded microspheres found in the range of 76.13% to 84.62%. The drug release study was done in simulated gastrointestinal fluids (SGF) for 12 hour and shown maximum amount of drug release in the controlled and sustained manner to extended periods of time. The DSC analysis and X-ray diffraction study indicated that the drug uniformly dispersed in amorphous state in molecular level. The drug release kinetic followed non-Fickain transport.


Cite this article:
Prashant N. Jorapur, Vinod M. Reddy, Vitthal K. Vijapure, Siddu Biradar, Vijaykumar A, Santosh Girani. Formulation and Evaluation of Gastroretentive Microspheres of Cefpodoxime Proxetil. Research J. Pharm. and Tech. 2017; 10(6): 1666-1674. doi: 10.5958/0974-360X.2017.00294.3


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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