Author(s): Jennifer Fernandes, B. C. Revanasiddappa, K. Ishwarbhat, M. Vijay Kumar, Lidwin D’Souza, Shanal Smitha Alva

Email(s): jennifer_pharma@yahoo.co.in

DOI: 10.5958/0974-360X.2017.00296.7   

Address: Jennifer Fernandes*, B. C. Revanasiddappa, K. Ishwarbhat, M. Vijay Kumar, Lidwin D’Souza, Shanal Smitha Alva
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical, Sciences of Nitte University, Paneer, Deralakatte, Mangalore-575 018, Karnataka, India
*Corresponding Author

Published In:   Volume - 10,      Issue - 6,     Year - 2017


ABSTRACT:
A new series of Chalcones (2a-j) were prepared by reacting 2-acetyl Pyrrole and substituted ketones in alcohol medium in presence of NaOH. The Chalcones undergoes selective cyclization with phenoxy acetic acid hydrazide (1) in glacial acetic acid medium to yield the title compounds 1,3,5-trisubstituted Pyrazolines (3a-j). The newly synthesized compounds were evaluated for their In-vitro anti-inflammatory activity by egg albumin denaturation and protein denaturation method. All the new compounds were established on the basis of 1H-NMR, IR and Mass spectral data. Some of the tested compounds 3a, 3f showed good anti-inflammatory activity when compared to the standard drug diclofenac sodium.


Cite this article:
Jennifer Fernandes, B. C. Revanasiddappa, K. Ishwarbhat, M. Vijay Kumar, Lidwin D’Souza, Shanal Smitha Alva. Synthesis and in-Vitro Anti-Inflammatory Activity of Novel Pyrazoline Derivatives. Research J. Pharm. and Tech. 2017; 10(6): 1679-1682. doi: 10.5958/0974-360X.2017.00296.7

Cite(Electronic):
Jennifer Fernandes, B. C. Revanasiddappa, K. Ishwarbhat, M. Vijay Kumar, Lidwin D’Souza, Shanal Smitha Alva. Synthesis and in-Vitro Anti-Inflammatory Activity of Novel Pyrazoline Derivatives. Research J. Pharm. and Tech. 2017; 10(6): 1679-1682. doi: 10.5958/0974-360X.2017.00296.7   Available on: https://rjptonline.org/AbstractView.aspx?PID=2017-10-6-19


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DOI: 10.5958/0974-360X 

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