Author(s): Neeraja Kamakshi. U, Ganga Rao. B, Venkateswara Rao. B

Email(s): neerajapvs@gmail.com

DOI: 10.5958/0974-360X.2017.00291.8   

Address: Neeraja Kamakshi. U*1, Ganga Rao. B2, Venkateswara Rao. B3
1Dept. of Pharmacognosy, K.C. Reddy Institute of Pharmaceutical Sciences, Jangamguntlapalem, Guntur, Andhra Pradesh, India.
2Dept. of Pharmacognosy, A.U College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India.
3Dept. of Pharmaceutical Analysis, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chowdavaram, Guntur, Andhra Pradesh, India.
*Corresponding Author

Published In:   Volume - 10,      Issue - 6,     Year - 2017


ABSTRACT:
Urolithiasis is a term used to describe calculi or stones formed in urinary tract. It involves the formation of calcifications in the urinary system, usually in the kidneys or ureters, but may also affect the bladder or urethra. It is a serious, debilitating problem in all societies throughout the world, affecting approximately, 12% of the population and men are three times more prone than women. It is more prevalent between the ages of 20 and 40 in both sexes. Present study is one of the attempts to compare Antilithiatic activity of various popularly known herbs with marketed formulation Cystone. Methanolic extracts of Aerva lanata, Sphaeranthus indicus, Merremia emarginata were compared with standard drug respectively by Spectrophotometric estimation of Calcium Oxalate and Calcium Phosphate dissolution models. Homogenous precipitation method was used to prepare artificial stones such as Calcium Oxalate and Calcium Phosphate and semi-permeable membrane of eggs was used as dissolution bags. Dissolution models were incubated for 72hrs and after that, the entire content in dissolution bags was estimated spectrophotometrically at 620 nms. In dissolution models all the extracts exhibited better dissolution of Calcium Oxalate and Calcium Phosphate crystals. However Cystone exhibited strong inhibitory action, whereas Methanolic extract of Aerva lanata showed almost similar activity, remaining shows considerably less inhibitory action at different concentrations than Standard. Phytochemical analysis revealed that all the plants showed presence of Alkaloids, Glycosides, Flavanoids, Lipids. Finally concluded that one of the above constituent may be responsible for the present activity. Further evaluation of these extracts as formulations are to be carry out.


Cite this article:
Neeraja Kamakshi. U, Ganga Rao. B, Venkateswara Rao. B. Comparison of In vitro Antiurolithiatic Activity of Aerva lanata, Sphaeranthus indicus, Merremia emarginata. Research J. Pharm. and Tech. 2017; 10(6): 1653-1656. doi: 10.5958/0974-360X.2017.00291.8


Recomonded Articles:

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6         Access: Open Access Read More

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0         Access: Open Access Read More

Author(s): Saranya, Parthasarathy V, Hariprasad B, Shobha Rani H

DOI: 10.5958/0974-360X.2016.00233.X         Access: Open Access Read More

Author(s): Ankita Chatterjee, Jayanthi Abraham

DOI: 10.5958/0974-360X.2016.00125.6         Access: Open Access Read More

Author(s): Hemlata M. Nimje, Rajesh J. Oswal, Sandip S. Kshirsagar, Manoj Chavan

DOI: Not Available         Access: Open Access Read More

Author(s): Swathy. S, Gheena. S, Sri Varsha. L

DOI: 10.5958/0974-360X.2015.00291.7         Access: Open Access Read More

Author(s): Rao Rekha, Goswami Anju, Shekhar Shishant, Mahant Sheefali, Nanda Sanju

DOI: Not Available         Access: Open Access Read More

Author(s): Rajendra Jangde, S. J. Daharwal

DOI: Not Available         Access: Open Access Read More

Author(s): A. Khuntia, S.K. Mohanty

DOI: Not Available         Access: Open Access Read More

Author(s): Pratik N. Shah, Bhavini N. Patel, Chaganbhai N. Patel

DOI: Not Available         Access: Open Access Read More

Author(s): Zain Mhanna, Wehad Ibrahim, Tamim Hammad

DOI: 10.5958/0974-360X.2016.00040.8         Access: Open Access Read More

Author(s): Kumaraswamy G., J.M. Rajendrakumar, J.V.L.N. Sheshagirirao, U. Ashok Kumar, M. Arunadevi

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags