Author(s): B. C. Revanasiddappa, M. Vijay Kumar, Prashanth Nayak, Ajmal Roshan Ali, M. S. Jisha

Email(s): evergreen_revan@rediffmail.com

DOI: 10.5958/0974-360X.2017.00261.X   

Address: B. C. Revanasiddappa*, M. Vijay Kumar, Prashanth Nayak, Ajmal Roshan Ali, M. S. Jisha
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical, Sciences of Nitte University, Paneer, Deralakatte, Mangalore-575 018, Karnataka, India
*Corresponding Author

Published In:   Volume - 10,      Issue - 5,     Year - 2017


ABSTRACT:
A novel series of Chalcones (2a-j) were prepared by reacting Furfuraldehyde and substituted ketones in alcohol medium in presence of NaOH. The Chalcones undergoes selective cyclization with Benzhydrazide (1) in glacial acetic acid medium to yield the title compounds 1,3,5-trisubstituted Pyrazolines (3a-j). All the newly synthesized compounds were evaluated for their In-Vitro antibacterial and antifungal activities. The new compounds were assigned on the basis of 1H-NMR, IR, Mass spectral data and elemental analysis. Some of the tested compounds showed potent activity against antifungal organism A.fumigatus.


Cite this article:
B. C. Revanasiddappa, M. Vijay Kumar, Prashanth Nayak, Ajmal Roshan Ali, M. S. Jisha. Synthesis, Antibacterial and Antifungal Evaluation of Novel Pyrazoline Derivatives. Research J. Pharm. and Tech. 2017; 10(5): 1481-1484. doi: 10.5958/0974-360X.2017.00261.X


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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